[PDF] BIOL-GA 1045 Protein Biochemistry - NYU Arts & Science

30006_7BIOL_GA1045_v202010.pdf

Instructor:

Andreas Hochwagen

Course Description:

Our objective is to give you a firm and rigorous foundation in the principles of modern protein biochemistry. These concepts form the basis for many of the great mechanistic advances now being made in biology and the medical sciences. In this course, we will discuss the fundamental processes that enable proteins to form complex biological structures, respond to the environment, catalyze chemical reactions and perform work. A strong emphasis will also be placed on the state-of-the-art experimental approaches driving the current revolution in biochemical research.

Pre-requisite:

Bio Core I (BIO-GA 1001) or

Molecular and Cellular Biology II (BIOL-UA 22)

Textbook and Required Materials:

Mike Williamson, How Proteins Work,1st edition

Amit Kessel & Nir Ben-Tal, Introduction to Proteins: Structure, Function and Motion, 2nd edition

Grading:

Midterm Exam I 30%

Midterm Exam II 30%

Final Exam 40%

Topics:

The RNA World and the Expanded Evolutionary Toolbox of Proteins Protein Structure and Underlying Molecular Forces

The Energetics of Protein Folding

The Kinetics of Protein Folding

Protein Domains and Intrinsically Disordered Proteins

Protein Structure Determination

Binding Equilibrium

Binding Dynamics

Oligomerization and Cooperative Binding

Protein Interactions in vivo

Protein Purification I

Protein Purification II

Proteomics

Introduction to Enzymatic Catalysis

Enzyme Kinetics

Defining a Reaction Path

The Active Site

Enzyme Geometry

Co-factors

Protein Regulation

Coupled Vectorial Processes I: Oxidative Phosphorylation Coupled Vectorial Processes II: Creating Movement

Protein Evolution