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Characteristics of benign and malignant cells and implications for diagnosis and assessment • Genetic, immunological and hormonal basis of cancer • Processes
This model suggests that each cancer cell has the ability to multiply and form new tumors The malignant cells have a selective advantage over their normal
Cancer is a disease of deregulated cellular behaviour Acquisition of oncogenic attributes, loss of tumour suppressive functions, evasion
Cancer is due to accumulation of mutations involving oncogenes, tumor suppressor genes, and DNA repair genes For example, colon cancer can begin with a defect
understanding of genomic alterations in cancer cells this brief overview that although many of the What is clear from this summary is that
The green boxes outline the 6 key characteristics of cancer cells 1 7 Bibliography 1 Chapter 2: The Biology of Cancer by Robert A Weinberg (Garland
Cells may acquire mutations in genes that control proliferation, such as proto-oncogenes Figure 1: Overview of the road to cancer and/or tumour suppressor
Conclusions: This review is not meant to be an exhaustive interpretation of carcinogenesis Consequently, cancer cells strive off to adapt, proliferate
genetically altered cancer cells and the host One caveat before exploring this typology: any attempt to organize a description of the nature of cancer