Activation of p53 may result in a cell cycle delay, presumably to allow an opportunity for DNA repair to occur before replication or mitosis (Hartwell and
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The best characterized activities of p53 are the induction of a cell growth arrest or of apoptosis Induction of a growth arrest by p53 was shown to
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The effect of p53 activation is to inhibit cell growth through cell cycle arrest (senescence) or induction of apoptosis, thereby suppressing tumor formation
10.1007%2F978-1-4020-2922-6_6.pdf
3 déc 2018 · apoptotic mechanism of p53 may promote the development of in vitro determine the cell cycle arrest during phases G1 / S, and acts on the
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Role of the p53 Tumor Suppressor Gene in Cell Cycle Arrest and Radiosensitivity of Burkitt's Lymphoma Cell Lines Patrick M O'Connor,1 Joany Jackman,
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When normal proliferating cells sustain DNA damage they respond in one of two ways: cell cycle arrest or apoptosis, and p53 is implicated in
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