[PDF] Design synthesis and biological activity evaluation of benzoate

What are the derivatives of local anesthetics?

derivatives compounds 7a–7c are structurally similar to many local anesthetics, such as dibucaine, mepivacaine, lidocaine and bupivacaine, which may have the same molecular spatial structure and have the same pharmacophilia. The mechanism of nerve block induced by local anesthesia can be distinguished

What are the different types of anesthetics?

Introduction Anesthetics are a type of drug that act on the nervous system, causing it to be inhibited and resulting in the loss of the sense of pain.1–4According to the di?erent scopes of action of drugs, the department of anesthetics is divided into general anes- thetics and local anesthetics.5–7General anesthetics act on the

How do local anesthetics and antiarrhythmics work together?

These new local anes- thetics have the biological activity of arrhythmia in addition to the e?ect of local anesthesia. Studies have shown that the local anesthesia and antiarrhythmic action mechanism is the same, mainly by blocking voltage-gated sodium channels, calcium channels and potassium channels, resulting in membrane

What is the effect of aniline on local anesthetic activity?

a signi?cant e?ect on the local anesthetic e?ect of the target compounds, and aniline replaces benzylamine to eliminate the local anesthetic activity of the target compounds. Thus, the durationofthelocalanestheticactivityofcompounds5g,5iand 5h was further determined by rat sciatic nerve block. The test