[PDF] Facteur XI

Why is factor XI important for hemostasis in vivo?

This topic last updated: Jun 19, 2023. Factor XI (eleven) is a plasma glycoprotein that acts in the contact phase of blood coagulation (the intrinsic pathway). Unlike the other contact factors (high molecular weight kininogen [HMWK], factor XII, and prekallikrein), factor XI is important for normal hemostasis in vivo.

What is factor XI deficiency?

Factor XI deficiency is sometimes called hemophilia C and is a relatively mild form of hemophilia. If you have factor XI deficiency, you might experience heavy menstrual periods, or bleeding after surgeries, such as dental extractions. Though there is no cure, treatments are available to help minimize symptoms and prevent future health problems.

Is factor XI autosomal recessive?

The mutation responsible for factor XI is autosomal recessive. It’s not linked to the sex chromosomes. To get factor XI deficiency from your parents, both parents need to have at least one copy of the factor XI mutation.

Which factor activates Factor X?

Factor IXa, in turn, forms a complex with Factor VIIIa (FIXa-FVIIIa) and activates factor X .