[PDF] Cross-Reactivity Among Amide-Type Local Anesthetics in a Case of





Previous PDF Next PDF



IgE-mediated allergy to local anaesthetics: separating fact from

† amino-ester compounds: benzocaine procaine



Cross-Reactivity Among Amide-Type Local Anesthetics in a Case of

Amide group. Allergy. Mepivacaine. Lidocaine. Ropivacaine. Bupivacaine. Levobupivacaine. Resumen. Las reacciones de carácter IgE mediado a los anestésicos 



Use of Local Anesthesia for Pediatric Dental Patients

13(pg81) Allergy to one amide does not rule out the use of another amide but allergy to one ester rules out use of another ester.31(pg347) Patients may 



Allergic manifestations to local anaesthetic agents for dental

Nevertheless some cases of allergic reactions to both esters and amides have been described [Caron



Allergies to local anesthetics — the real truth

ested to know that a non-ester non-amide



Meta-xylene: identification of a new antigenic entity in

Oct 1 2015 Allergic reactions to both ester and amide LAs are very rare.4. We report ... Allergy to local anesthetics: specific IgE · demonstration to both ...



HYPERSENSITIVITY TO LOCAL ANAESTHETICS – 6 FACTS AND

ester-LAs and type I reactions to amide-LAs has never been described. Ruzicka et Allergy to local anesthetics of the amide group with tolerance to procaine.



Anesthetic Technique For Elective Cesarean Section In A Patient

Allergic reaction to local anesthetic agents of the amide group. J Allergy Clin Immunol. 1997 Dec;100(6 Pt 1):855. 5. Fuzier R Lapeyre-Mestre M



Hypersensitivity to local anaesthetics â•fi update and proposal of

As prevalent subtypes of ester and amide LAs are available both as top- ical Allergy to local anesthetics of the amide group with tol- erance to procaine ...





Use of Local Anesthesia for Pediatric Dental Patients

19-Apr-2007 istration of local anesthesia.67 In pediatric dentistry



IgE-mediated allergy to local anaesthetics: separating fact from

agents as allergenic triggers in contrast to esters probably reflects the current practice of preferential use of amide agents for local anaesthesia.



Is it ester or amide?

True allergic reactions to local anesthetics are rare and usually involve an ester agent. Allergic reactions are seldom caused by amide anesthetic agents.



Investigation and diagnosis of an immediate allergy to amide local

amide local anaesthetic in a paediatric dental patient. G Allen*. D Chan



Cross-Reactivity Among Amide-Type Local Anesthetics in a Case of

Amide group. Allergy. Mepivacaine. Lidocaine. Ropivacaine. Bupivacaine. Levobupivacaine. Resumen. Local anesthetics can be classified as ester type—.



Allergic manifestations to local anaesthetic agents for dental

Nevertheless some cases of allergic reactions to both esters and amides have been described [Caron



The Eyes Have It: Eyelid Swelling and Rash in a 79-year-old

Due to her positive hypersensitivity testing to 2 ester anesthetics the patient underwent skin prick and intradermal testing to the amide anesthetic



Hypersensitivity to local anaesthetics â•? update and proposal of

Key words: allergy; contact allergy; lidocaine; local anaesthetics; treatment; type 1; type 4. This figure presents one ester (benzocaine) and one amide.



Guideline on Use of Local Anesthesia for Pediatric Dental Patients

19-Apr-2007 of local anesthetic chemical formulations: (1) esters (eg procaine



An Update on Local Anesthetics in Dentistry

02-Oct-2002 joined by an amide or ester linkage to a carbon chain ... Patient reports of allergic reactions to local anesthetics.

J Investig Allergol Clin Immunol 2006; Vol. 16(5): 311-313© 2006 Esmon Publicidad

P Gonz·lez-Delgado, et al

Case Report

Cross-Reactivity Among Amide-Type

Local Anesthetics in a Case of Allergy

to Mepivacaine

P González-Delgado,

1

R Antón,

2

V Soriano,

1

P Zapater,

3

E Niveiro

1 1 Sección Alergia, Hospital General de Alicante, Aliccante, Spain 2 Servicio de Anestesia, Hospital General de Elche, Alicante, Spain 3 Servicio de Farmacología, Hospital General de Alicante, Alicante, Spain

Abstract. Among the various adverse reactions to local anesthetics, IgE-mediated reactions, particularly to the

more commonly used amide group, are extremely rare. We report the case of a 39-year-old man who suffered

itching and generalized urticaria with facial angioedema 15 minutes after administration of mepivacaine. Skin

tests revealed a strong positive reaction to mepivacaine, lidocaine, and ropivacaine, but negative reactions to

bupivacaine and levobupivacaine. Furthermore, double-blind placebo-controlled subcutaneous challenge with

bupivacaine and levobupivacaine was well tolerated.

We conclude that an extensive allergologic study must be carried out in rare cases of true allergic reaction to

amide-type local anesthetics in order to rule out cross reactivity.

Key words: Local anesthetics. Amide group. Allergy. Mepivacaine. Lidocaine. Ropivacaine. Bupivacaine.

Levobupivacaine.

Resumen. Las reacciones de carácter IgE mediado a los anestésicos locales, especialmente a los del grupo amida,

que son los más utilizados, son extremadamente infrecuentes. Se notificó un paciente de 39 años que presentó

prurito y urticaria generalizada a los 10 minutos de recibir mepivacaína subcutánea. Los test cutáneos con

mepivacaína fueron claramente positivos, así como con lidocaina y ropivacaina. Los test cutáneos con bupivacaína

y levobupivacaina fueron negativos. El test de provocación controlada doble ciego con bupivacaina y

levobupivacaina fué bien tolerado.

Podemos concluir que en el caso infrecuente de sensibilización a anestésicos locales del grupo amida, antes de

prescribir otro fármaco del mismo grupo, es conveniente realizar un estudio alergológico completo para descartar

la existencia de reacción cruzada .

Palabras clave: Anestésicos locales. Grupo amida. Alergia. Mepivacaína. Lidocaína. Ropivacaína. Bupivacaína.

Levobupivacaína.

Introduction

A variety of complications associated with procedures involving local anesthesia have been described. Most are thought to involve toxic effects or be related to the surgical procedure requiring local anesthesia. Today there is good evidence in the literature that IgE-mediated reactions to pure local anesthetics, particularly to the more commonly used amide group, are extremely rare [1].

Case Description

A 39-year-old man attended our Allergy Unit for

evaluation of an adverse reaction to local anesthetics. The patient reported an episode of itching and generalized urticaria that took place 15 minutes after administration of mepivacaine (Scandinibsa, Inibsa, Barcelona, Spain)

3 months earlier during a nevus extirpation. No other

drugs were administered during the procedure. The J Investig Allergol Clin Immunol 2006; Vol. 16(5): 311-313© 2006 Esmon Publicidad

Cross Reactivity of Amide-Type Local Anesthetics

urticaria was resolved in a few hours following treatment with oral corticosteroids and antihistamines. Povidone- iodine was used as a local antiseptic during the surgical procedure but the patient tolerated the antiseptic after this episode. The patient had not undergone local anesthesia since the episode. He had no personal or family history of allergy. The complete blood count and biochemical profile were within the normal range. Total serum IgE was

51 kU/L. The results of a skin prick test were negative

for a battery of standard aeroallergens, foods, latex, and Anisakis simplex. Prick and intradermal tests withquotesdbs_dbs3.pdfusesText_6
[PDF] amide ir

[PDF] amide local anesthetics metabolism

[PDF] amide or ester local anesthetic

[PDF] amide synthesis from ester

[PDF] amide synthesis from ester mechanism

[PDF] amide to carboxylic acid hydrolysis

[PDF] amide to carboxylic acid reaction

[PDF] amide vs ester local anaesthetics

[PDF] amide vs ester local anesthetic

[PDF] amides can be formed by the reaction of which of the following?

[PDF] amine + hcl mechanism

[PDF] amine + koh

[PDF] amine acetic acid reaction

[PDF] amine acetylation mechanism

[PDF] amine alcohol condensation