[PDF] amine group and acid reaction

When reacted with acids, amines donate electrons to form ammonium salts. Acid halides react with amines to form substituted amides. Aldehydes and ketones react with primary amines to give a reaction product (a carbinolamine) that dehydrates to yield aldimines and ketimines (Schiff bases).
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  • What happens to amine in acidic conditions?

    Under the acidic conditions of this reaction, all amines undergo reversible salt formation: This happens with 3º-amines, and the salts are usually soluble in water.

  • How does amine group react with HCl?

    By simply reacting the drug molecule's amine functional group with a strong acid like HCl, the amine salt is formed, and the compound is rendered water soluble, and thus more bioavailable.

  • Do amines react with strong acids?

    Nearly all amines, including those that are not very soluble in water, will react with strong acids to form salts soluble in water.
    Amine salts are named like other salts: the name of the cation is followed by the name of the anion.

  • Do amines react with strong acids?

    Amine are basic and easily react with the hydrogen of acids which are electron poor as seen below.
    Amines are one of the only neutral functional groups which are considered bases which is a consequence of the presence of the lone pair electrons on the nitrogen.

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