NOMENCLATURE EN CHIMIE ORGANIQUE 1. Hydrocarbures (HC
NOMENCLATURE EN CHIMIE ORGANIQUE. La nomenclature permet de : a) Trouver le nom d'une molécule Groupe principal : Suffixe = -amide. -carboxamide.
I. Connaissance sur les amides II. Les différentes classes damides
) remplace le groupe hydroxyle (–OH) de la molécule d'acide carboxylique. Page 2. III. Les composés du carbone. 131. III. Nomenclature des
Chapter 6 Amines and Amides
Learn the major chemical reactions of amines and amides and learn how to predict the products of amide synthesis and hydrolysis reactions. • Learn some of the
sch_206-amides.pdf
IUPAC Nomenclature of Amides. Primary Amides. 4. An amide is named based on the recognition that it is a composite of a carboxylic acid and ammonia or an
Page 1 sur 14 Les Acides aminés et les protéines
1. Nomenclature. Les acides aminés sont des ions dipolaires (zwitterion) dans leur état naturel : En effet ils sont solubles dans l'eau
Chapter 17: Amines and Amides
* Because the suffix here is -diamine which starts with a consonant the terminal -e of the alkane name is retained. Naming aromatic amines. 17.4 Isomerism for
CHM 2520 Chimie organique II
considérons la préparation et les réactions de quatre dérivés : 1. chlorures d'acide. 2. anhydrides. 3. esters. 4. amides.
NOMENCLATURE ET ISOMERIE
L'atome de carbone du groupe -. COOH porte toujours le numéro 1; comme pour les aldéhydes et les amides l'indice 1 est omis. acide pentanoïque et NON acide
La fonction amide.pdf
R R' et R" sont des atomes d'hydrogène ou des groupements alkyles. 2. NOMENCLATURE. Le nom de l'amide dérive de celui de l'alcane de même chaîne carbonée en
bi102-2017-acides amines.pdf
Thréonine Thr T. Nomenclature des acides aminés : On utilise un code soit à 3 lettres soit à 1 lettre. II-Structure des acides aminés. Figure 6
Amides
Definition
1 An amide is a composite of a carboxylic acid and either ammonia or an amine.R may be H, alkyl or aryl.
Amides are derivatives of carboxylic acids, derived by combining carboxylic acids with amines.12:21 PM
Natural Amides
2 Amides are prevalent in nature and serve diverse but key structural and physiological roles. These are present in complex structural proteins such as keratin or in key hormones such as insulin. Peptide bonds of peptides and proteins are amide bonds. Amides also occur naturally in simple systems such as caffeine and melatonin, a hormone biosynthesized from tryptophan, that controls the sleep-wake cycle. People with high levels of melatonin sleep longer and more soundly than those with low levels.12:21 PM
Classification of Amides
3 Amides are classified according to the number of substituents (non-hydrogen-like groups) connected to the nitrogen of the amide group. Note that the carboxyl group is also treated as a substituent to the nitrogen. Unlike alcohols, the classification of amides relates to the substitution at the nitrogen rather than substitution on carbon. CNH2R O CHNR O RCNR ORRStructure
# of groups on nitrogenOneTwoThree ClassificationPrimary amideSecondary amideTertiary amide12:21 PMIUPAC Nomenclature of Amides
Primary Amides
4 An amide is named based on the recognition that it is a composite of a carboxylic acid and ammonia or an amine. Primary amides are, thus, named by replacing the suffix oic acid in the IUPAC name of the parent carboxylic acid of the amide by the suffix amide.Primary Amides
CNH2R O COHR O +NH3Carboxylic acidAmmonia
Examples
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Names of Secondary and Tertiary Amides
5 In the naming of secondary and tertiary amides, the alkyl groups on nitrogen are treated as substituents, and their position is specified by the prefix N- to differentiate them from any substituents located on the parent chain of the parent carboxylic acid. If more than one substituent is bonded to nitrogen, they are stated alphabetically followed by the name of the amide. Substituents on the acyl component are designated with the usual locators (2,3.. etc) as appropriate.Example
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Synthesis of Amides
Preparative Strategies
6 Highlighted below are the most common strategies by which amides are prepared. The amides are commonly prepared from the reaction of carboxylic acids, acid chlorides and acid anhydrides with amines.12:21 PM
Reaction of Carboxylic Acids with Amines in
Presence of DCC
7 Primary and secondary amines react with carboxylic acids in the presence of DCC to form amides. DCC serves to activate the carboxyl group of the carboxylic acid to aid in coupling to the amino group. +COHR O1,3-Dicyclohexylcarbodiimide
+C OHNHNDicyclohexylurea
(DCHU)R'NH2CHNR
O +CNN (DCC) R' Amide Trimetozine is a sedative and an anti-anxiety drug that is readily made from eudesmic acid and morpholine using DCC.Reaction of Acid Chlorides with an Amine
8 Acid chlorides, with a good leaving group attached to the carbonyl group, react with ammonia and amines through a nucleophilic acyl substitution to provide amides.Example
Trimetozine is commonly used as a sedative and an anti-anxiety drug. CCl O MeO MeOMeOOHNNaOH
H2OCN O MeO MeOMeOONaCl
MorpholineTrimetozine
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Reaction of Acid Anhydrides with an
Amine 9 Just like acid chlorides, acid anhydrides also react with ammonia and amines through a nucleophilic acyl substitution to provide amides.Example
Paracetamol is a pain reliever found in medicines such asPanadol and Tylenol.
+COR OR'NH2CHNR
OR'+COHR
O CR O12:21 PM
Reactions of Amides
10 Amides are the most stable carboxylic acid derivatives and consequently the least reactive of the carboxylic acid derivatives. The diminished reactivity of amides is more because they exist in the imidate form rather than as a true amide. The imidate formation significantly reduces the electrophilicity of the carbon of the carbonyl. Consequently, amides undergo relatively fewer reactions.12:21 PM
Hydrolysis of Amides
11 The hydrolysis of amides is much more difficult compared to that of esters. Consequently, they require much harsher conditions usually by heating under either acidic or basic conditions for a prolonged period. The hydrolysis of amides in acidic media provides a carboxylic acid and an ammonium salt. Due to the high stability of amides, their hydrolysis requires heating at 110 oC in concentrated acid for about 12 hours.12:21 PM
Reduction of Amides to Amines
12 RNR'
O R' RNR' R'LiAlH4
H2O (1) (2) The reduction of amides with a strong reducing agent (LiAlH4) provides an amine of the same classification as the parent amide. The reaction provides a path by which amines of various classifications can be synthesized from amides and ultimately from carboxylic acids. 12:21 PMMechanism of Reduction of Amides
1312:21 PM
Mechanism of Reduction of Amides
1412:21 PM
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