[PDF] acetyl coa thioester

The central metabolite acetyl CoA is a thioester that is produced mainly by oxidative decarboxylation of pyruvate or by fatty acid degradation. The primary fates of acetyl CoA are to enter the citric acid cycle or to contribute to fatty acid synthesis.
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  • What is the thioester bond acetyl-CoA?

    This thioester linkage is a "high energy" bond, which is particularly reactive. Hydrolysis of the thioester bond is exergonic (?31.5 kJ/mol). CoA is acetylated to acetyl-CoA by the breakdown of carbohydrates through glycolysis and by the breakdown of fatty acids through ?-oxidation.27 jan. 2016

  • What is CoA thioester?

    Acyl-CoAs are a family of metabolic intermediates comprised of an acyl group linked by a thioester bond to coenzyme A.

  • What is the function of a thioester?

    Thioesters are involved in the synthesis of all esters, including those found in complex lipids. They also participate in the synthesis of a number of other cellular components, including peptides, fatty acids, sterols, terpenes, porphyrins, and others.
  • Introduction to thioesters and Coenzyme A
    In the metabolism of lipids (fats and oils), thioesters are the principal form of activated carboxylate groups. They are employed as acyl carriers, assisting with the transfer of acyl groups such as fatty acids from one acyl X substrate to another.
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Synthesis of acyl-CoA thioesters - DEV MANGROO AND GERHARD

Synthesis of acyl-CoA thioesters. Biochem. Cell Biol. 68: 308-3 12. An improved syn<hesis of fatty acyl coenzyme A has been developed that permits the 



A Reversed Thioester Analogue of Acetyl-Coenzyme A: An Inhibitor

15?/04?/1998 of Thiolase and a Synthon for Other Acyl-CoA Analogues ... The reversed thioester analogue of acetyl-CoA may have useful applications in.





The steady state concentrations of coenzyme A-SH and coenzyme A

02?/05?/1975 Coenzyme A Thioester Citrate



Changes in Size of Intracellular Pools of Coenzyme A and Its

Key words: CoA; Acetyl-CoA; Malonyl-CoA; Acyl-CoA. Cycling Method; Escherichia coli. Coenzyme A (CoASH) and its thioesters are inter-.



Identification and Characterization of Mitochondrial Acetyl

The origin of plastid acetyl-CoA for fatty acid synthesis has been the subject of considerable CoA thioester was measured directly with the DTNB assay.



Acyl Carrier Protein

of '4CO2 into the malonyl thioester. Thus it appeared that. P-ketoacyl-ACP synthetase might itself catalyze fatty acyl transfer between CoA and ACP.



Substrate specificity of acetyl coenzyme A synthetase.

09?/10?/1986 Coenzyme A (CoA) thioesters are essential substrates for enzymes that catalyze fatty acid and polyketide biosynthesis. (1). These enzymes ...



A Single LC-MS/MS Analysis to Quantify CoA Biosynthetic

21?/07?/2021 CoA acts as an acyl group carrier forming thioester linkages with organic acids to yield acyl CoAs (e.g. acetyl CoA or palmitoyl CoA) [1]. The ...



Thioester synthesis by a designed nickel enzyme models prebiotic

18?/07?/2022 the carbon monoxide dehydrogenase/acetyl coenzyme A synthase (CODH/ACS) com- ... for generation of the thioester acetyl-CoA (Eq. 2) ...