[PDF] acetylation of phenol using acetic anhydride

Phenols are not acetylated by acetic anhydride alone in carbon tetrachloride, but addition of pyridine leads to acetylation. Alcohols, in contrast, are acetylated in the absence of pyridine, but the extent of catalysis by pyridine is less than for phenols.
View PDF Document


  • How does phenol react with acetic anhydride?

    When acetic anhydride reacts with phenol in the presence of a base, then phenyl acetate is obtained.

  • How is acetylation with acetic anhydride done?

    In a 5 ml round-bottom flask, 1 g of 4a–h was added to an equimolar amount of acetic anhydride containing 1% of VOSO4·5H2O. The reaction was kept under stirring for 2 or 24 h at room temperature. The reaction was then quenched with 50 ml of H2O and kept under stirring for about 15 min.

  • What is the mechanism for the acetylation of an alcohol with acetic anhydride?

    Initially, acetic acid protonates the carbonyl group of acetic anhydride to give a cationic intermediate which is further attacked by the nucleophile to give an alcohol-type intermediate.
  • (iii) Acetyl chloride is more reactive and hence more liable to undergo side reaction. Therefore acetic anhydride is preferred for acylation.
View PDF Document




Facile and Efficient Acetylation of Primary Alcohols and Phenols with

3 ?.?. 2556 Calcium carbonate and cobaltous carbonate did not promote the acetylation of 4-ntirobenzyl alcohol using acetic anhydride. The acetylation of 4- ...



Acetylation of alcohols phenols and salicylic acid by heteropoly

HPAs have been used as catalysts for acetylation of alcohols phenols and salicylic acid with acetic anhydride. The performance of different forms of 



FULL PAPER Chemoselective Acylation of Amines in Aqueous Media

acetylated over phenol (Scheme 1). This observation is in. Table 1. Acetylation of amines with acetic anhydride. [a] Confirmed by comparison with IR 



Simple and Efficient Method for Acetylation of Alcohols Phenols

Abstract: Solvent-free acetylation of alcohols phenols



A Convenient and Chemoselective Acetylation and Formylation of

alcohols with acetic acid acetyl chloride and acetic anhydride in the literature.1-14 Formylation is also a very important process in organic chemistry and 



Synthesis of paracetamol by acetylation

Supplementary Material. The object of the present experiment is to synthesize an aromatic amide by addition-elimination reaction with acetic anhydride.



Acetylation of phenols using acetic acid

Under the conditions of our experiments there is no indication of the formation of any acetic anhydride and the acetylation seems to have been effected by the 



Catalytic Friedelâ•?Crafts Acylation Reactions

such as phenols and aromatic amines preferentially occurs at the substituent The acylation of anisole with acetic anhydride is carried out in a flow.



RAPID AND EFFICIENT ACETYLATION OF ALCOHOLS AND

RAPID AND EFFICIENT ACETYLATION. OF ALCOHOLS AND PHENOLS WITH. ACETIC ANHYDRIDE USING TIN(IV). PORPHYRIN AS CATALYST. Shahram Tangestaninejad*.



Sulfamic Acid Catalysed Acetylation of Alcohols and Phenols with

Abstract: An easy acetylation of alcohols and phenols with acetic anhydride has been carried out in excellent yield under catalysis of sulfamic acid.