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Research Report 2015

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Research Report 2015

4c_U1-U4_maxplanck_Titel_2015.indd 113.10.2015 14:29:25

Imprint | Research Report 2015

Published by the Max Planck Institute for Molecular Genetics (MPIMG),

Berlin, Germany, Oktober 2015

Editorial Board: Bernhard G. Herrmann & Martin Vingron

Coordination: Patricia Marquardt

Photos &

Scientifi c Illustrations:

MPIMG

Production: Thomas Didier, Meta Druck

Copies: 500

Contact: Max Planck Institute for Molecular Genetics

Ihnestr. 63 - 73

14195 Berlin

Germany

Phone: +49 (0)30 8413-0

Fax: +49 (0)30 8413-1207

Email: info@molgen.mpg.de

For further information about the MPIMG, see http://www.molgen.mpg.de

Cover image

3D-rendered light sheet micrograph of the caudal end of an E9.5 mouse embryo

illustrating the generation of neuroectoderm (green cells) and mesoderm (red cells) from common progenitor cells (yellow cells, mostly located deep in the tissue) during trunk development. The neuroectoderm gives rise to the spinal cord, the mesoderm to the vertebral column, skeletal muscles and other tissues. Picture taken by Frederic Koch,

Manuela Scholze, and Matthias Marks, MPIMG.

4c_U1-U4_maxplanck_Titel_2015.indd 24c_U1-U4_maxplanck_Titel_2015.indd 213.10.2015 14:29:2613.10.2015 14:29:26

MPI for Molecular Genetics

Research Report 2015

Research Report 2015

Max Planck Institute for Molecular Genetics

Berlin, September 2015

The Max Plank Institute

for Molecular Genetics

Ada Yonath, Nobel laureate in chemistry 2009 and former member of the MPIMG, at the celebratory symposium on the

occasion of the institute"s 50th anniversary in December 2014.

MPI for Molecular Genetics

Research Report 2015

Table of contents

The Max Planck Institute for Molecular Genetics 7

Department of Developmental Genetics (B.G. Herrmann) 21

Introduction 22

Department of Computational Molecular Biology (M. Vingron) 45

Introduction 45

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Research Group Evolutionary Genomics (P. Arndt) 85

General information about the whole department 94

Research Group Development & Disease (S. Mundlos) 113

Introduction 114

Otto Warburg Laboratory

Max Planck Research Group Epigenomics (H.-R. Chung) 153

Resear

ch Group RNA Bioinformatics (A. Marsico) 163

Sofja Kovalevskaja Resear

ch Group

Long non-coding RNA (U.A. Ørom)

173
BMBF

Research Group

Nutrigenomics & Gene Regulation (S. Sauer)

183

Max Planck Resear

ch Group

Regulatory Networks in Stem Cells (E. Schulz)

195

Max Planck Resear

ch Group

Molecular Interaction Networks (U. Stelzl)

203

Resear

ch Group Gene Regulation and Systems

Biology of Cancer (M.-L. Yaspo)

215
BMBF

Research Group

Cell Signaling Dynamics (Z. Zi)

229

Minerva Gr

oup Neurodegenerative disorders (S. Krobitsch) 235

The Max Plank Institute

for Molecular Genetics

Max Planck Fellow Group

Emeritus Gr

oup Vertebrate Genomics (H. Lehrach) 255

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