[PDF] Using static method to measure tolmetin solubility at different





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Welcome to Objective-C

Objective-C classes are defined in an @interface directive. to a static method in Java. ... Objective-C does not call object methods as Java does.



Factory Pattern

using static methods or abstract factory objects. Objective-C has a powerful pattern called a class cluster that implement the factory pattern right in the 



Using static method to measure tolmetin solubility at different

https://doi.org/10.1038/s41598-020-76330-9 www.nature.com/scientificreports. Using static method to measure tolmetin solubility at different.



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    In object oriented programming, static method is a method that is associated with a class. Therefore, static methods do not have the capability to operate on a particular instance of a class. Static methods can be invoked without using an object of the class that contains the static method.

How to define a static method in C# 8?

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How to declare a method in Objective-C?

    An Objective-C method declaration includes the parameters as part of its name, using colons, like this: - (void)someMethodWithValue:(SomeType)value; As with the return type, the parameter type is specified in parentheses, just like a standard C type-cast.

What is the difference between static and non static methods?

    Static methods are methods that are associated with a class, whereas non static methods are methods that are associated with objects of a class. A class needs to be instantiated first to invoke a non static method, but static methods do not have this requirement. They can be simply invoked using the name of the class that holds the static method.
| (2020) 10:19595 | www.nature.com/scientificreports indomethacin1,2 .Unfortunately,similar syndrome 2 .Respectingthesefacts,it

The Faculty of

Department of Chemical Sciences, Bernal Institute,

University of Limerick, Limerick, Ireland.

Department of Process Engineering, Research and Development

Department of Chemical Engineering, Faculty

Department of Chemistry,

Department for Management of Science and

Chemical Engineering Faculty, Sahand University of

Laboratory of Computational Modeling of

email: azam.marjani@ tdtu.edu.vn

Vol:.(1234567890)

| (2020) 10:19595 | www.nature.com/scientificreports/ area 3 inwater,itcanbesubjectedtoamicronizationprocesstoreduceitssizetoavaluebelow10 µm 3 sinceaccording level 4 5 below5 µm,athinnerdi?usionlayeraroundtheparticleswouldbeestablishedandtherateofdrugabsorption druginthebody 6,7 (CO 2 )asthe diclofenac 8 sulindac 9 ,fenoprofen 10 ,piroxicam 11 ,etc. hydrochloride 12 ,sulindac 13 ,?uoxetine hydrochloride 14 trioctylmethylammonium 15 ,piroxicam 16 ,etc. 17 -21 22
,23 ,arti?cialneural network 24
,25 ,and,semi-empiricaldensity basedcorrelations 26
,27 validatedinliteratureforpredictionof solubility 28
,29 2 usingaPVTcelllinkedwithwell-knowngravi metrictechniqueismeasuredunderwiderangesofpressures(120-400 bar)andtemperatures(308-338 K)for 2 accordingtothebestknowledgeof ?esemodelsinclude:Bartleet al. 30
,Garlapatiand

Madras

27
,Mendez-SantiagoandTeja(MST) 31
,Chrastil 32
,and

Kumar-Johnston(KJ)

33

Tolmetin(C

15 H 15 NO 3 ),CASnumberof26171-23-3,withmolecularweightof257.29 g gmol -1 2 (purity >99.8%)at338 Kand

500 bartopurify

it 34

FanavariAtiyeh

PouyandeganExirCompany(Arak,Iran),andisshowninFig. 1.?eapplicabilityandreliabilityofthesystem CO 234
.?e uredtoobtainthevaluesofsolubility.AsshowninFig. 1,theheartofprocessisthePVTcell(volume=0.4L) CO 2 isgeneratedandsenttoPVTcell foundelsewhere 18 19 21
34
Inmeasuringthesolubilityoftolmetin,eightdi?erentpressures(120to400 bar, interval40 bar)wereset,whilethecelltemperaturesweresetatfourvalues,i.e.308,318,328,and338 K.?e ?eexperimentalsolubilitydataoftolmetinisshowninFig. 2andlistedinTable 1alongwithstandarddevia- -5 and2.59 10 -3 molfraction(seeTable 1).Itisclearlyobservedthatthetolmetinsolubilityisastrongfunctionof isobservedathighertemperatures,e.g.338 K.Ontheotherhand,thee?ectoftemperatureisinitiallydecreas ing,andthenincreasinga?eracertainpoint(around160 bar).?ispointisknownascross-overpointinwhich

Vol.:(0123456789)

| (2020) 10:19595 | www.nature.com/scientificreports/

Figure 1.

SC-CO 2 drugsolubility apparatus 19 .Reprinted from 19 ,Copyright(2020),withpermissionfrom

Elsevier.

Figure 2.

Solubilityvaluesoftolmetin.

Table 1. Solubilityoftolmetin.Standarduncertainty(u),areu(T)=0.1 Kandu(P)=0.35 bar.

P/barT/K

308318328338

ySDySDySDySD

1201.39×10

-4 1.20 10 -5 8.83 10 -5 5.06 10 -6 6.80 10 -5 1.46 10 -6 5.00 10 -5 2.68 10 -6

1602.39×10

-4 1.89 10 -5 2.35 10 -4 1.05 10 -5 1.86 10 -5 5.32 10 -6 1.82 10 -4 4.99 10 -6

2002.97×10

-4 1.51 10 -5 3.65 10 -4 2.21 10 -5 4.69 10 -4 3.28 10 -5 4.93 10 -4 2.32 10 -5

2403.55×10

-4 1.89 10 -5 4.70 10 -4 2.56 10 -5 6.64 10 -4 4.16 10 -5 8.41 10 -4 5.69 10 -5

2804.21×10

-4 2.84 10 -5 6.34 10 -4 4.73 10 -5 8.74 10 -4 6.98 10 -5 1.24 10 -3 7.65 10 -5

3204.98×10

-4 2.34 10 -5 7.85 10 -4 5.52 10 -5 1.18 10 -3 1.44 10 -5 1.65 10 -3 1.11 10 -4

3605.53×10

-4 4.44 10 -5 9.40 10 -4 6.44 10quotesdbs_dbs21.pdfusesText_27
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