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Lutilisation de lemblème européen dans le contexte des
L'Union européenne (UE) gère de nombreux programmes de financement qui soutiennent des projets et des initiatives dans différents domaines en son sein et
CESRs Guidelines on Risk Measurement and the Calculation of
19 Apr 2010 CESR 11-13 avenue de Friedland
Point prevalence survey of healthcare-associated infections and
11 Feb 2013 to estimate the total burden (prevalence) of HAIs and antimicrobial use in acute care hospitals in the EU;. • to describe HAIs (sites ...
ECDC
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REPORT ON THE USE OF DIGITAL PLATFORMS
sector including the use of digital platforms
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Point prevalence survey of
healthcare-associated infections and antimicrobial use in European acute care hospitals2011-2012
Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals
ECDC SURVEILLANCE REPORT
Point prevalence survey of healthcare-
associated infections and antimicrobial use in European acute care hospitals 20112012
ii
This report of the European Centre for Disease Prevention and Control (ECDC) was coordinated by Carl Suetens.
Contributing authors
Carl Suetens,
Acknowledgements
We would like to thank Andrew J. Amato-Gauci, Ole Heuer, Phillip Zucs, Dominique L. Monnet, Denis Coulombier,
many other colleagues at ECDC and the ECDC PPS coordination expert team members for their kind review of the report or otherwise contributing to the HAI -Net PPS project and especially all the national PPS coordination teammembers, local hospital staff, and other contributing experts for their hard work and dedication in collecting and
reporting the data, reviewing the draft report or otherwise contributing to the success of this survey. More detail
can be found in the Acknowledgements section on page 116.The country summary sheets are included in Annex 2 of the online report at: www.ecdc.europa.eu/publications
Suggested citation: European Centre for Disease Prevention and Control.Point prevalence survey of healthcare-
associated infections and antimicrobial use in European acute care hospitals. Stockholm: ECDC; 2013.Stockholm, July 2013
ISBN 978-92-9193-485-0
doi 10.2900/86011Catalogue number TQ-01-13-314-EN-C
© European Centre for Disease Prevention and Control, 2013Reproduction is authorised, provided the source is acknowledged SURVEILLANCE REPORT PPS of HAI and antimicrobial use in European acute care hospitals 2011-2012 iii
Contents
Abbreviations
Overview
Summary of results
Introduction
Characteristics of hospitals and patients
Healthcare-associated infections
Antimicrobial use
Discussion
Recommendations
Conclusions
Background and objectives
Methodology
Participation
Protocol
Standard and light protocols
Sampling of hospitals
Inclusion criteria
Questionnaires (data collection forms)
Case definitions for healthcare-associated infectionsInclusion of antimicrobial agents
Data collection and processing
National PPS protocols and tools
Training
Validation of PPS data
Data analysis
Recoding of variables
Indicators
Statistical analysis
Results
Participation
Hospital and patient characteristics
Hospital type and size
Length of stay
Ward and patient/consultant specialty
Patient demographics and risk factors (patient-based data only)Hospital indicators
Alcohol hand rub consumption
Single rooms/beds
Infection control staff
Healthcare-associated infections
Main results, aggregated
Results by country
Antimicrobial use
Main results
Results by country
Burden estimates
Prevalence burden estimates: number of patients with an HAI or antimicrobials on any given day Incidence burden estimates: number of patients per year with an HAI Burden estimates for specific HAI types and microorganismsDiscussion
Healthcare-associated infections
Antimicrobial use
Structure and process indicators
Limitations
Data representativeness
Data validity
Adjustment for case mix
Burden estimates
Limitations of structure and process indicators
Conclusions
PPS of HAI and antimicrobial use in European acute care hospitals 2011-2012 SURVEILLANCE REPORT ivRecommendations
References
Acknowledgements
Annex 1. Tables
SURVEILLANCE REPORT PPS of HAI and antimicrobial use in European acute care hospitals 2011-2012 vFigures
Figure 1. Distribution of HAI types by presence of HAI on admission, HAI present on admission (left) HAI onset
during hospitalisation (right)Figure 2. Observed HAI prevalence with 95% confidence intervals and predicted HAI prevalence based on case mix
and hospital characteristics, by country, ECDC PPS 2011-2012Figure 3. Clostridium difficile infections and other gastro-intestinal infections (excluding hepatitis) as a percentage
of all HAIs, by country, ECDC PPS 2011-2012Figure 4.
Percentage of Enterobacteriaceae isolates from HAIs non-susceptible to third-generation cephalosporins,
by country, ECDC PPS 2011-2012 Figure 5. Indications for antimicrobial use in European acute care hospitals, ECDC PPS 2011-2012Figure
6. Prevalence of antimicrobial use (percentage of patients receiving antimicrobials) in acute care hospitals,
ECDC PPS 2011-2012
Figure 7. Percentage of antimicrobials for which the reason for use was documented in the patient's records, by
country, ECDC PPS 2011-2012 Figure 8. Period of participation in the first EU-wide PPS, 2011-2012 Figure 9. Sample representativeness in the ECDC PPS by country, 2011-2012Figure 10. Hospital size (number of hospital beds, left) and type of hospital (right) in 947 hospitals included in the
ECDC PPS 2011-2012
Figure 11. Correlation between the mean length of stay (in days) in participating hospitals (hospital data) and the
mean length of stay for all hospitals in the country (national data), including all beds (left, n=27 countries) and acute care beds only (right, n=18 countries)Figure 12. Correlation between the mean length of stay (in days) in participating hospitals (hospital data) and the
mean (left) and median (right) length of stay from date of admission until the survey date (patient data,
n=30 countries with patient-based data) Figure 13. Comparison of ward (left) versus patient/consultant (right) specialty, ECDC PPS 2011-2012 Figure 14. Distribution of patient/consultant specialty by country, ECDC PPS 2011-2012 Figure 15. Median alcohol hand rub consumption (litres per 1000 patient-days), ECDC PPS 2011-2012Figure 16. Distribution of the consumption of alcohol hand rub (litres per 1000 patient-days) by country, ECDC PPS
2011-2012
Figure 17. Median percentage of single-room beds among the total number of hospital beds, ECDC PPS 2011-2012
Figure 18. Distribution of the percentage of single -room beds by country, ECDC PPS 2011-2012Figure 19. Median number of infection prevention and control nurse full-time equivalents (FTE) per 250 hospital
beds (n=866 hospitals), ECDC PPS 2011-2012Figure 20. Number of infection prevention and control nurse (IPCN) full-time equivalents (FTE) per 250 hospital
beds by country (n=866 hospitals), ECDC PPS 2011-2012Figure 21. Median number of infection prevention and control doctor full-time equivalents (FTE) per 250 hospital
beds (n=779 hospitals), ECDC PPS 2011-2012Figure 22. Number of infection prevention and control doctor (IPCD) full-time equivalents (FTE) per 250 hospital
beds, by country (n=779 hospitals), ECDC PPS 2011-2012Figure 23. Distribution of HAI types by presence of HAI on admission (left) and HAI onset during hospitalisation
(right), ECDC PPS 2011-2012Figure 24. Prevalence of HAI (percentage patients with an HAI) by hospital type (left) and size (n of beds) (right),
n=947 hospitals, ECDC PPS 2011 -2012Figure 25. Prevalence of HAI (percentage of patients with an HAI) (left) and distribution of HAI types (right) by
patient/consultant specialty, n=231 459 patients, ECDC PPS 2011 -2012Figure 26. Observed HAI prevalence with 95% confidence intervals and predicted HAI prevalence based on patient
case mix and hospital characteristics, by country, ECDC PPS 2011-2012Figure 27. Correlation between the observed and predicted prevalence of HAI, by country, ECDC PPS 2011-2012
Figure 28. Correlation between the observed prevalence of HAI and the prevalence of antimicrobial use for
prescriber-labelled 'treatment of a hospital infection'*, by country, ECDC PPS 2011-2012Figure 29. Distribution of the observed HAI prevalence, by hospital, according to the probability of the observed
result (n=947 hospitals), ECDC PPS 2011-2012Figure 30. Relationship between the absolute difference between the observed and predicted HAI prevalence and
the percentage of hospitals with a lower than 5% probability of the observed HAI prevalence, ECDC PPS
2011-2012 Figure 31. Percentage of HAIs present on admission, by country, ECDC PPS 2011-2012 Figure 32. Origin of HAIs, by country, ECDC PPS 2011-2012
Figure 33. Distribution of the day of onset of HAIs not present on admission, by country, ECDC PPS 2011-2012
Figure 34. Distribution of HAI types, by country, ECDC PPS 2011-2012 PPS of HAI and antimicrobial use in European acute care hospitals 2011-2012 SURVEILLANCE REPORT viFigure 35. Clostridium difficile infections and other gastro-intestinal infections (excluding hepatitis) as a percentage
of all HAIs, by country, ECDC PPS 2011-2012Figure 36. Relative frequency of catheter-related infections as a total of all HAIs, by country, ECDC PPS 2011-2012
Figure 37. Percentage of HAIs with non-negative microbiological results on the PPS day, ECDC PPS 2011-2012
Figure 38. Relative frequency of Escherichia coli isolates as a percentage of all microorganisms reported for HAIs,
by country (n=1601 isolates), ECDC PPS 2011 -2012Figure 39. Relative frequency of Staphylococcus aureus as a percentage of all microorganisms reported for HAIs,
by country (n=1243 isolates), ECDC PPS 2011-2012Figure 40. Relative frequency of Enterococcus spp. as a percentage of all microorganisms reported for HAIs, by
country (n=969 isolates), ECDC PPS 2011 -2012Figure 41. Relative frequency of Klebsiella pneumoniae as a percentage of all microorganisms reported for HAIs, by
country (n=689 isolates), ECDC PPS 2011 -2012Figure 42. Relative frequency of Clostridium difficile as a percentage of all microorganisms reported for HAIs, by
country (n=548 isolates), ECDC PPS 2011-2012Figure 43. Relative frequency of Acinetobacter spp. as a percentage of all microorganisms reported for HAIs, by
country (n=366 isolates), ECDC PPS 2011-2012Figure 44. Percentage of isolates with known antimicrobial susceptibility testing (AST) results (first-level AMR
markers combined) for HAIs, by country, ECDC PPS 2011-2012Figure 45. Percentage of meticillin-resistant S. aureus isolates from HAIs, by country (n=1071 isolates), ECDC PPS
2011-2012
Figure 46. Percentage of Enterobacteriaceae isolates from HAIs non-susceptible to third-generation cephalosporins
by country (n=2851 isolates), ECDC PPS 2011 -2012Figure 47.
Percentage of Enterobacteriaceae isolates from HAIs non-susceptible to carbapenems, by country (n=2787 isolates), ECDC PPS 2011 -2012Figure 48. Percentage of Klebsiella spp. isolates from HAIs non-susceptible to carbapenems, by country (n=726
isolates), ECDC PPS 2011-2012Figure 49. Percentage of P. aeruginosa isolates in HAIs non-susceptible to carbapenems, by country (n=756
isolates), ECDC PPS 2011-2012Figure 50. Percentage of Acinetobacter baumannii isolates from HAIs non-susceptible to carbapenems, by country
(n=292 isolates), ECDC PPS 2011 -2012Figure 51. Percentage of glycopeptide-resistant E. faecalis isolates from HAIs, by country (n=455 isolates), ECDC
PPS 2011
-2012Figure 52. Percentage of glycopeptide-resistant E. faecium isolates from HAIs, by country (n=205 isolates), ECDC
PPS 2011
-2012............................................................................................................................ 69
Figure 53. Percentage of glycopeptide-resistant Enterococcus spp. (VRE) isolated from HAIs, by country (n=755
isolates), ECDC PPS 2011-2012Figure 54. Composite index: percentage of isolates non-susceptible to first-level antimicrobial resistance markers
from HAIs, by country (n=5725 isolates), ECDC PPS 2011-2012 Figure 55. Indications for antimicrobial use in European acute care hospitals, ECDC PPS 2011-2012Figure 56. Distribution of antimicrobial use in acute care hospitals on the day of the survey, by ATC level 2 group
(n= 110151 antimicrobial agents), ECDC PPS 2011
-2012 Figure 57. Distribution of use of ATC group J01 (antibacterials for systemic use ) in acute care hospitals on the day of the survey (n= 101 866 antimicrobial agents), ECDC PPS 2011 -2012Figure 58. Distribution of use of ATC group J01C (beta-lactam antibacterials, penicillins) in acute care hospitals on
the day of the survey (n= 31 673 antimicrobial agents), ECDC PPS 2011-2012Figure 59. Distribution of use of ATC group J01D (Other beta-lactam antibacterials) in acute care hospitals on the
day of the survey (n= 28 717 antimicrobial agents) , ECDC PPS 2011 -2012Figure 60. Distribution of use of ATC group J01X (Other antibacterials) in acute care hospitals on the day of the
survey (n= 12 012 antimicrobial agents), ECDC PPS 2011-2012Figure 61. Antimicrobial agents accounting for 75% of antimicrobial use in European acute care hospitals (DU
75%), ECDC PPS 2011
-2012Figure 62. Prevalence of antimicrobial use (percentage of patients on antimicrobials), by hospital type (left) and
size (right), n=947 hospitals (vertical black line=overall median), ECDC PPS 2011-2012Figure 63. Prevalence of antimicrobial use (percentage of patients on antimicrobials) by patient/consultant specialty
(left) and indication for antimicrobial use by patient/consultant specialty (right), ECDC PPS 2011-2012
Figure 64. Distribution of antibacterials for systemic use (ATC group J01) by patient/consultant specialty, ECDC PPS
2011-2012
Figure 65. Prevalence of antimicrobial use (percentage of patients receiving antimicrobials) in acute care hospitals,
ECDC PPS 2011-2012
Figure 66. Observed prevalence of antimicrobial use with 95% confidence intervals and predicted prevalence of
antimicrobial use based on case mix and hospital characteristics, by country, ECDC PPS 2011-2012 SURVEILLANCE REPORT PPS of HAI and antimicrobial use in European acute care hospitals 2011-2012 viiFigure 67. Correlation between the observed and predicted prevalence of antimicrobial use (AU) by country, ECDC
PPS 2011
-2012 Figure 68. Indications for antimicrobial use by country, ECDC PPS 2011-2012Figure 69. Surgical prophylaxis given for more than one day as a percentage of the total antimicrobials prescribed
for surgical prophylaxis, by country, ECDC PPS 2011-2012 Figure 70. Percentage of antimicrobials prescribed for medical prophylaxis, ECDC PPS 2011-2012Figure 71. Percentage of antimicrobials for which the route of administration was parenteral, ECDC PPS 2011-2012
Figure 72. Percentage of antimicrobials for which the reason for use was documented in the patient's records,
ECDC PPS 2011-2012
Figure 73. Distribution of antimicrobial groups by ATC third level and by country, (J01 antibacterials for systemic
use), ECDC PPS 2011-2012Figure 74. Distribution of antimicrobial use by country, ATC group J01C (Beta-lactam antibacterials, penicillins),
ECDC PPS 2011-2012
Figure 75. Distribution of antimicrobial use by country, ATC group J01D (Other beta-lactam antibacterials), ECDC
PPS 2011
-2012Figure 76. Prevalence of carbapenem (J01DH) use (percentage of hospitalised patients receiving carbapenems),
ECDC PPS 2011-2012
Figure 77. Distribution of antimicrobial use by country, ATC group J01M (Quinolone antibacterials), ECDC PPS
2011-2012
Figure 78. Distribution of antimicrobial classes by ATC fourth level and by country, J01X (Other antibacterials),
ECDC PPS 2011-2012
Figure 79. Prevalence of glycopeptide (J01XA) use (percentage of hospitalised patients receiving glycopeptide
antibacterials), ECDC PPS 2011-2012Figure 80. Prevalence of use of polymyxins (ATC group J01XB) and/or tigecycline (percentage of hospitalised
patients receiving any of these antibacterials), ECDC PPS 2011-2012Figure 81. Prevalence of use of oral metronidazole (P01AB01) and/or oral vancomycin (A07AA09) (percentage of
hospitalised patients receiving any of these antimicrobials), ECDC PPS 2011-2012 Figure 82. Prevalence of use of antimycotics (ATC group J02 and nystatin) (percentage of hospitalised patients receiving any antimycotic for systemic use), ECDC PPS 2011-2012Figure 83. Scatterplot showing prevalence of antimicrobial use in acute care hospitals (%, ECDC PPS 2011-2012)
and antimicrobial consumption of ATC groups J01 and J02 in the hospital sector (re -calculated as DDD per 1 000 patient-days, numerator data from ESAC-Net, 2010 (a) ; denominator data from ECDC PPS 2011-2012)
Tables
Table 1. Total number of acute care hospitals and hospital beds, and participation in the ECDC PPS by country, 2011-2012 Table 2. Type and size of hospitals included in the ECDC PPS 2011-2012 Table 3. Distribution of the patient demographics, patient-based data, ECDC PPS 2011-2012
Table 4. Distribution of the patient risk factors, patient-based data, ECDC PPS 2011-2012 ................................. 31
Table 5.
Alcohol hand rub consumption (litres per 1000 patient-days) by hospital type, ECDC PPS 2011-2012 (data
for the preceding year, 2010 or 2011)Table 6.
Percentage of single
-room beds among the total number of hospital beds by hospital type, ECDC PPS 2011-2012
Table 7. Distribution of the number of infection prevention and control nurse FTE per 250 hospital beds by hospital
size , ECDC PPS 2011-2012Table 8. Distribution of the number of infection prevention and control nurse FTE per 250 hospital beds by hospital
type , ECDC PPS 2011-2012Table 9. Distribution of the number of infection prevention and control doctor FTE per 250 hospital beds by
hospital type , ECDC PPS 2011-2012Table 10. Distribution of the number of infection prevention and control doctor FTE per 250 hospital beds by
hospital size, ECDC PPS 2011-2012Table 11.
Prevalence of HAI by HAI type and relative frequency of HAI types, ECDC PPS 2011-2012Table 12.
Characteristics of HAIs: origin of HAIs, association with invasive device use, origin of bloodstream infections, ECDC PPS 2011-2012Table 13.
Microorganisms isolated in healthcare
-associated infections by infection type, ECDC PPS 2011-2012Table 14.
Antimicrobial resistance markers in microorganisms reported in healthcare-associated infections, ECDC
PPS 2011
-2012Table 15.
Percentile distribution of the prevalence of HAI (percentage patients with an HAI) by hospital type, ECDC
PPS 2011
-2012 PPS of HAI and antimicrobial use in European acute care hospitals 2011-2012 SURVEILLANCE REPORT viiiTable 16.
Patient risk factors for HAIs with crude and adjusted odds ratios derived from multiple logistic regression
model, n=215 537 patients in 30 countries (standard protocol data only), ECDC PPS 2011-2012Table 17.
Results of national PPS validation surveys from four countries: HAI prevalence , ECDC PPS 2011 -2012Table 18.
Relative frequency (percentage) of microorganisms most commonly reported for HAIs, by country, ECDCPPS 2011
-2012Table 19.
Indication for antimicrobial use, route of administration and documentation of the reason for antimicrobial use in the patient notes, ECDC PPS 2011-2012 Table 20. Site of diagnosis for antimicrobial treatment of infections, ECDC PPS 2011-2012Table 21. Distribution of antimicrobials (fourth ATC level*) as a percentage of the total number of antimicrobials,
by indication, ECDC PPS 2011-2012Table 22.
Percentile distribution of the prevalence of antimicrobial use, by hospital type , ECDC PPS 2011 -2012Table 23.
Patient risk factors for antimicrobial use with crude and adjusted odds ratios from multiple logistic
regression model, n=215 537 patients in 30 countries, standard protocol data only, ECDC PPS 2011- 2012Table 24.
Results of national PPS validation surveys in four countries: prevalence of antimicrobial use (AU)Table 25.
Estimation of the number of patients with at least one HAI and the number of patients receiving at least
one antimicrobial (AU) on any day in acute care hospitals, ECDC PPS 2011-2012 Table 26. Estimated number of (patients with) HAIs on any given day, by HAI type, ECDC PPS 2011-2012Table 27.
Estimation of the annual number of patients acquiring at least one HAI in acute care hospitals, ECDC PPS
2011-2012
Table 28.
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