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What is Clostridioides difficile infection (CDI)?

This topic last updated: May 11, 2023. Clostridioides difficile infection (CDI) is one of the most common hospital-acquired (nosocomial) infections and is an increasingly frequent cause of morbidity and mortality among older adult hospitalized patients [ 1-3 ]. CDI is also increasingly diagnosed in younger patients and in the community.

How is Clostridium difficile infection diagnosed in patients with diarrhoea?

Discussion Clostridiumdifficile infection should be suspected in patients with diarrhoea (? 3 loose stools within 24 h) of unexplained origin. Many laboratory studies can be implemented in CDI diagnosis. Those methods are based on direct detection of bacteria as well as one or both major toxins (A and B) in stool.

What are the guidelines for management of chronic inflammatory bowel disease (CDI)?

The guidelines discuss management of adult patients (over 18 years of age) of both sexes with symptoms suggestive of CDI, with the diagnosis confirmed based on current criteria, regardless of the type or severity of symptoms. In addition, recommendations for managing CDI also include patients with recurrent infection. 1.2.

Is CDI a symptom of antibiotic-associated colitis?

CDI is also increasingly diagnosed in younger patients and in the community. C. difficile colonizes the human intestinal tract after the normal gut flora has been disrupted (frequently in association with antibiotic therapy) and is the causative organism of antibiotic-associated colitis including pseudomembranous colitis.