BLOCKER – DOES NOT POTENTIATE CHLOROQUINE ANTIPLASMODIAL ACTIVITY a calcium channel blocker –, and also the combination isradipine plus Isradipine (Icaz® LP, Laboratoires Sandoz, France) test Martin et al ( 1987)
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Isradipine – a calcium channel blocker – does not - Parasite
BLOCKER – DOES NOT POTENTIATE CHLOROQUINE ANTIPLASMODIAL ACTIVITY a calcium channel blocker –, and also the combination isradipine plus Isradipine (Icaz® LP, Laboratoires Sandoz, France) test Martin et al ( 1987)
Calcium Channel Blockers
The publisher and editor can give no guarantee for the information on drug The drugs named calcium channel blockers (CCBs) were initially termed cal- channel inhibitors (and in French anticalciques) term potentiation or depression (LTPILTD) [431, 528], and to the tolerance amlodipine, felodipine, isradipine,
[PDF] Differential Involvement of Ca Channels in Survival and - CORE
Scientifique, Université de Rennes 1, 35042 Rennes Cedex, France Received 5 lack of effect on IBa, isradipine, nifedipine, and -CgTx GVIA did not induce cell death calcium channel blockers, n is the Hill coefficient, and IC50 the concentration MARSHALL J Akt-dependent potentiation of L channels by insulin-like
Molecular determinants of the differential modulation of Cav12 and
6 juil 2018 · This article has not been copyedited and formatted which block and potentiate L-type voltage-gated Ca2+ channels Biologic RSC 160 perfusion system ( BioLogic, Sayssinet-Pariset, France) (isradipine) for a Cav1 3 clone from human pancreas (Cav1 38A) type calcium channel alpha 1 subunits
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The monographs do not carry the drug interaction Hazard/Severity rat- One French study found that 16 of the prescriptions for a group of pa- tients taking duces the metabolism of oral calcium-channel blockers Although altering may potentiate the adverse effects of ACE inhibitors and angiotensin II an- tagonists on
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Note de recherche
Parasite, 2005, 12, 187-189
ISRADIPINEÐ A CALCIUM CHANNEL BLOCKERÐ
DOES NOT POTENTIATE CHLOROQUINE ANTIPLASMODIAL ACTIVITYAGAINSTPLASMODIUM FALCIPARUM
RANDRIANARIVELOJOSIA M.*
** & JAMBOU R. *Summary:
Culturing fresh clinical isolates of P. falciparumand using the isotopic method, we tested separately chloroquine and isradipine Ð a calcium channel blocker Ð, and also the combination isradipine plus chloroquine. Tested wild isolates were chloroquine- sensitive. With regard to the combination isradipine/chloroquine, the isobolograms obtained indicate that isradipine antagonises chloroquine antiplasmodial activity. Taking into account these findings, we discuss the issues related to the calcium channel blocker molecules. Résumé : L'ISRADIPINEÐUN INHIBITEUR DE CANAUX CALCIQUESÐSURPLASMODIUM FALCIPARUM
Des isolats de P. falciparumfraîchement prélevés de malades ont ŽtŽ testŽs pour Žvaluer leurs rŽponses in vitroà la chloroquine, à lÕisradipine (un inhibiteur de canaux calciques), et ˆ la combinaison isradipine/chloroquine. Les tests de chimiosensibilitŽ ont ŽtŽ rŽalisŽs avec la mŽthode isotopique. Ces isolats sauvages Žtaient sensibles ˆ la chloroquine. Quant ˆ la combinaison isradipine/chloroquine, les isobologrammes obtenus indiquent un antagonisme entre les deux molŽcules. Tenant compte de ces rŽsultats, nous soulevons dans cet article lÕimportance de la comprŽhension du mŽtabolisme calcique des parasites du paludisme ; et lÕŽnigme de la rŽversion de la chloroquinorŽsistance par certaines molŽcules inhibitrices des canaux calciques. KEY WORDS :chloroquine, isradipine, Plasmodium falciparum, Madagascar. MOTS CLÉS :chloroquine, isradipine, Plasmodium falciparum, Madagascar.MATERIAL AND METHODS
IN VITROPLASMODIUM FALCIPARUMCHEMOSENSITIVITY
TESTS C linical P. falciparumisolates were collected from consenting patients in Saharevo. Samples were transported to the Malaria Research Unit at the ÒInstitut Pasteur de MadagascarÓ where the isotopic in vitrochemosensitivity tests were performed. Chloro- quine diphosphate (Sigma Chemicals) was tested as described elsewhere (Randrianarivelojosia et al., 2002).Isradipine (Icaz
LP, Laboratoires Sandoz, France) test
M artin et al. (1987) demonstrated that the cal- cium channel blocker verapamil, a phenylal- kylamine, reverses chloroquine resistance in Plasmodium falciparum. Subsequent studies were then carried out to assess the nature of the interaction bet- ween antimalarial molecules and different calcium channel blockers in P. falciparumin order to have new means of controlling drug resistant parasites (Scheibel et al., 1987; Kyle et al., 1990). Most of the studies of the interaction between channel blockers and antima- larial drugs were performed with P. falciparumclones maintained in continuous cultures. In this preliminary study, in vitrotesting was carried out with Malagasy (Madagascar) fresh isolates of P. falciparumexposed to dihydropyridine channel blocker isradipine (Fig. 1), a calcium channel blocker which is frequently pres- cribed to treat essential hypertension (Persson et al.,1989), and to chloroquine.
* Groupe de Recherche sur le Paludisme, Institut Pasteur de Mada- gascar. ** Natural Products Research Group, School of Chemistry, Univer- sity of KwaZulu-Natal, Durban, 4041, South Africa. *** UnitŽ dÕImmunologie, Institut Pasteur de Dakar, BP 220, SŽnŽgal. Correspondence: Dr Milijaona Randrianarivelojosia, Groupe Recher- che sur le Paludisme, Institut Pasteur de Madagascar, BP 1274, Anta- nanarivo (101) Madagascar. Fax: +261 20 22 415 34 Ð E-mail: milijaon@pasteur.mgFig. 1. - Chemical structure of isradipine.Article available athttp://www.parasite-journal.orgorhttp://dx.doi.org/10.1051/parasite/2005122187
concentrations ranged from 2 to 200 µM. The effect of isradipine on the activities of the antimalarials was determined by combination test (Martin et al., 1987). The chloroquine-resistant strain P. falciparumFCM29 maintained in continuous culture was also tested imme- diately after synchronization using the sorbitol-based method (Lambros & Vanderberg, 1979).