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GC CHROMATOGRAMS PHARMACEUTICAL Organic Volatile Impurities: Retention Time Index G16 G16 G43 Retention Time Retention Time 8 26 15 28 13 55 acetic acid 3 22 47 20 34 6 52 4 61 8 84 8 96 acetone 3 3 02 2 64



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[PDF] Organic Volatile Impurities: Retention Time Index - PDF2 - Chromtech

GC CHROMATOGRAMS PHARMACEUTICAL Organic Volatile Impurities: Retention Time Index G16 G16 G43 Retention Time Retention Time 8 26 15 28 13 55 acetic acid 3 22 47 20 34 6 52 4 61 8 84 8 96 acetone 3 3 02 2 64



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GC CHROMATOGRAMS |

PHARMACEUTICAL

Organic Volatile Impurities: Retention Time Index

G

G1166GG1166GG4433GG2277GG11NNAA

Carrier gas: heliumIICCHHSSttaabbiillwwaaxx

R Rttxx -WWAAXXRRttxx -11330011RRxxii -55mmssRRttxx -11RRttxx -220000 C

CoommppoouunnddCCllaassssRReetteennttiioonn TTiimmeeRReetteennttiioonn TTiimmeeRReetteennttiioonn TTiimmeeRReetteennttiioonn TTiimmeeRReetteennttiioonn TTiimmeeRReetteennttiioonn TTiimmee

1,4-dioxane28.557.497.867.2613.5414.34

1-butanol311.1310.087.185.7611.4910.13

1-pentanol314.9513.7511.199.4416.9914.95

1-propanol37.696.804.203.376.816.13

2-butanol37.256.445.084.168.517.69

2-methyl-1-propanol39.328.406.004.79**

2-propanol34.814.253.002.554.914.69

acetic acid322.4720.346.524.618.848.96 acetone33.022.642.892.504.647.68 acetonitrile26.915.833.282.474.328.89 anisole318.6517.0917.1216.2825.0022.84 benzene15.234.545.983.8311.639.17 butyl acetate38.867.8812.1211.3819.4319.63 carbon tetrachloride13.963.495.615.9011.897.42 chloroform27.316.415.234.649.186.66 cumene312.3611.1716.6616.6925.8820.90 cyclohexane22.162.015.375.89** dichloromethane25.014.333.313.065.874.88 ethanol34.984.372.522.194.033.80 ethyl acetate34.083.564.874.449.0410.35 ethyl benzene210.729.5813.8613.8122.5418.18 ethyl ether31.721.632.582.675.343.87 ethyl formate33.162.783.002.785.466.48 ethylene glycol228.0626.2310.776.6312.5913.86 formamide232.9930.9311.857.3012.7219.93 formic acid324.6422.095.192.605.595.06 heptane31.981.866.346.9814.187.84 hexane21.651.583.774.119.064.86 isobutyl acetate36.996.1810.399.6917.3518.02 isopropyl acetate34.263.746.195.7111.4712.38 methanol24.233.641.961.803.142.93 methyl acetate33.192.803.172.935.807.10 methylbutyl ketone29.108.0511.8110.5017.9420.81 methylethyl ketone34.333.764.904.097.9911.55 methylisobutyl ketone36.845.979.648.4915.3518.41 m-xylene211.2110.0414.2914.1723.0118.78 nitromethane211.8210.314.843.536.3012.01 o-xylene212.7911.5115.4615.2624.2320.33 pentane31.491.452.392.625.363.29 propyl acetate35.985.298.037.44** p-xylene210.989.8214.2914.1722.9918.69 pyridine212.6411.249.608.5715.4016.45 sulfolane247.6243.3134.0228.9036.7648.67 tert-butylmethyl ether31.941.823.503.597.525.73 tetrahydrofuran33.633.195.124.909.819.48 tetralin225.1223.4827.4927.4437.2731.72 toluene27.866.919.809.6617.3614.00

1,1-diethoxypropane - 5.424.8411.3911.3819.8215.08

2,2-dimethoxypropane - 3.112.795.485.5511.378.67

2-chloropropane - 1.961.822.672.665.204.61

2-methylpentane - 1.581.523.223.567.724.32

acetaldehyde - 2.051.851.861.843.143.90 chloroethane - 1.831.712.142.103.973.55 chloromethane - 1.631.551.701.703.012.73 ethylene oxide - 2.051.861.892.023.593.92 formaldehyde - 2.251.571.681.582.662.59 isoamyl acetate - 10.519.4314.8414.1822.8022.62 isooctane - 1.851.755.846.5913.668.07 isopropyl ether - 1.861.764.034.239.035.83 methyl cyclopentane - 1.911.794.504.9310.415.81 methyl isopropyl ketone - 4.934.296.585.6911.0414.47 methylal - 2.262.062.842.825.655.09 trichloroethene - 6.505.707.077.0513.589.75

water - 8.247.181.741.682.752.57* Not determinedRReetteennttiioonn ttiimmee ddaattaa ccoolllleecctteedd uussiinngg tthhee ffoolllloowwiinngg ccoonnddiittiioonnss::

G16 Stabilwax®:30m, 0.25mm ID, 0.5µm df, Phase ratio: 125, Oven program: 40ºC, hold 1 min., to 190ºC @ 4ºC/min., hold 15 min., Carrier flow: 1.2mL/min., Dead time: 1.38 min. @ 45ºC

G16 Rtx®-WAX: 30m, 0.25mm ID, 0.5µm df, Phase ratio: 125, Oven program: 40ºC, hold 1 min., to 190ºC @ 4ºC/min., hold 15 min., Carrier flow: 1.2mL/min., Dead time: 1.40 min. @ 45ºC

G43 Rtx®-1301:30m, 0.25mm ID, 1.0µm df, Phase ratio: 63, Oven program: 40ºC, hold 1 min., to 190ºC @ 4ºC/min., hold 15 min., Carrier flow: 1.

2mL/min., Dead time: 1.40 min. @ 45ºC

G27 Rxi®-5ms:30m, 0.25mm ID, 1.0µm df, Phase ratio: 63, Oven program: 40ºC, hold 1 min., to 190ºC @ 4ºC/min., hold 15 min., Carrier flow: 1.

1mL/min., Dead time: 1.49 min. @ 45ºC

G1 Rtx®-1:60m, 0.53mm ID, 3.00µm df, Phase ratio: 43, Oven program: 30ºC, hold 4 min., to 220ºC @ 4ºC/min., Carrier flow: 6.3mL/min., Dead time: 2.54 min. @ 35ºC

Rtx®-200:60m, 0.53mm ID, 3.00µm df, Phase ratio: 43, Oven program: 30ºC, hold 4 min., to 220ºC @ 4ºC/min., Carrier flow: 7.8mL/min., Dead time: 2.22 min. @ 35ºC

Reduce method development time-use a retention time index for column selection.

675-700_GCappPharm.qxp 11/22/2010 9:31 PM Page 696Website : www.chromtech.net.au E-mail : info@chromtech.net.au TelNo : 03 9762 2034 . . . in AUSTRALIA Mar 2011

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