2 Lecture outline • Dendritic cells and antigen presentation • The role of the MHC • T cell activation • Costimulation, the B7:CD28 family
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2 Lecture outline • Dendritic cells and antigen presentation • The role of the MHC • T cell activation • Costimulation, the B7:CD28 family
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B cell generation, Activation, and Differentiation - B cells mature in the bone marrow - B cells proceed through a number of distinct maturational stages:
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HIV persists in cellular reservoirs despite durable antiretroviral T cell activation Distinct HIV/SIV infection outcomes Immune activation Noel et al AIDS 2014
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3 T-cell activation T cells migrate to secondary lymphoid tissues where they interact with antigen, antigen-presenting cells, and other lymphocytes: 4 Naïve
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cells recognize antigen in context of major histocompatibility molecules, with important accessory molecules that serve to control T cell activation and prevent
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