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[PDF] USANA Clinical Research Bulletin - Comparative Bioavailability of

signed to compare the bioavaila- bility of CoQ10 as delivered by four formulas, including a new, proprietary, all-natural formula developed by USANA scientists

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1 Recommended Citation: Cuomo J, Rabovsky A. Comparative Bioavailability of Coenzyme Q 10 in Four Formu- lations. 2000. USANA Clinical Research Bulletin, USANA Health Sciences, Inc. SLC, UT.

CLINICAL RESEARCH BULLETIN

Comparative Bioavailability of Coenzyme Q

10 in Four Formulations * USANA Health Sciences, Inc. Salt Lake City, Utah, USA. oenzyme Q10 (CoQ10) plays an essential role in mitochondrial electron transport, and as such it is fun- damental for energy production in cells. 1

Further, CoQ10 is an an-

tioxidant whose activity is par- ticularly important in regenerat- ing vitamin E. Its ability to quench free-radicals also helps maintain the structural integrity and stability of mitochondrial and cellular membranes - including intracellular membranes.2

Studies

have shown therapeutic benefits for CoQ10 supplementation, the best documented of which involve cases of heart failure and ischem- ic heart disease.3

Because CoQ10 is a lipid-

soluble nutrient, its bioavailabili- ty from pharmaceutical and nu- tritional products can be limited.

USANA uses a patented solubili-

zation system in its current Co-

Quinone product, which is highly

effective in promoting high CoQ10 absorption. However, many of the solubilizing ingre- dients are synthetic, and ideally an all-natural formula would be preferable. This study was de- signed to compare the bioavaila- bility of CoQ10 as delivered by four formulas, including a new, proprietary, all-natural formula developed by USANA scientists.

Methods

This prospective crossover

study involved 14 healthy subjects.

Four coenzyme Q10 formulations

were prepared: a dry tablet with- out cyclodextrins, a dry tablet containing a preformed cyclodex- trin-CoQ10 complex, the current

USANA CoQuinone liquid formu-

la in a soft-gel capsule, and USA-

NA's new proprietary liquid for-

mula in a hard gelatin capsule.

Given the crossover design, each

subject participated in each of the four treatments in serial fa- shion, with a washout period (six days) between treatments. On the morning of the first test, subjects reported to the la- boratory for a baseline blood draw. After the blood draw, each participant was given a CoQ10 supplement with a standard meal.

Additional blood samples were

then drawn at 3, 5, and 8 hours after supplementation. This pro- tocol, beginning with a baseline blood draw, was repeated three more times as the subjects ro- tated through the four treatments.

All blood samples were

processed, and plasma fractions were analyzed for CoQ10 via

HPLC with an electrochemical

detector. Increases from baseline in plasma CoQ10 concentrations were calculated, and statistical comparisons between treatments were run. In addition, increases in plasma CoQ10 were plotted as a function of time following sup- plementation, and area under the curve (AUC) was calculated as an indicator of bioavailability over C 2 Recommended Citation: Cuomo J, Rabovsky A. Comparative Bioavailability of Coenzyme Q 10 in Four Formu- lations. 2000. USANA Clinical Research Bulletin, USANA Health Sciences, Inc. SLC, UT. time. Statistical comparisons were also made for these AUCs.

Results

The four formulas showed

dramatic differences in CoQ10 bioavailability (Figures 1 and 2).

The dry tablet formula without

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