Age at disease onset and diagnosis delay in HLA-B27 negative vs PDF s00296-002-0237-4.pdf

The frequency of ju- venile disease onset (before age 16 years) is nearly the same, irrespective of the B27 status Keywords Ankylosing spondylitis Æ HLA- B27 Æ

bowel disease, or psoriasis In this group B27 is mostly negative form spondylitis more often in B27+ patients

differences between HLA-B27 positive and HLA-B27 negative disease

These results suggest that seasonal environmental factors may play a role in the production of HLA-B27 negative AAU diseases known as the seronegative spondylarthro- pathies, and most patients with these spondylarthro- pathies and those who develop AAU after enteric infection carry the HLA-B27 antigen

FALSE-NEGATIVE SEROLOGICAL HLA-B27 TYPING RESULTS

originally tested to be HLA-B27 positive and 10 HLA-B27 negative by the MLCT disease, 144 with Yersinia- and nine with Salmonella- Submitted 19 April