[PDF] Reactions involving carbonyl compounds

I Nucleophilic addition reactions Carbonyl group of aldehyde, ketone, carboxylic acid, ester etc , a The C-O bond is polarized towards the more electronegative oxygen Bonding in In order to get product in good yields, it is necessary to

Relative Reactivity of Carboxylic Acid Derivatives Towards Nucleophilic Attack We need to be able to rationalise this order of reactivity In essence the more δ+ charge on the carbonyl carbon, the more electrophilic is the group and more reactive it is towards nucleophilic addition

[PDF] Nucleophilic addition to the carbonyl group

Molecular orbitals explain the reactivity of the carbonyl group We are now You met nucleophilic addition to a carbonyl group on pp 115 and 121 The polarization of the antibonding π* orbital towards carbon is also ketones Having introduced you to the sequence of events that makes up a nucleophilic attack at C=O

Reactions of Carbonyl Compounds

In many reactions at carbonyl groups, a key step is addition of a nucleophile, For acetaldehyde, the half-life of the exchange reaction is on the order of 1 transfer in activating the carbonyl group toward nucleophilic attack, (2) the reactivity

Addition, Condensation and Substitution Reactions of Carbonyl

of carbonyl compounds toward addition of nucleophiles Several factors The reactivity of carbonyl compounds toward hydration parallels the order indicated in

[PDF] Chemical reactivity of carbonyl compounds - International Journal of

The observed reactivity order is shown below: into the reactivity scale towards nucleophiles: additions of alcohols to aldehydes and ketones take place The