[PDF] ANTIBIOTIC DOSES - Sheffield Childrens Hospital



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ANTIBIOTIC DOSES - Sheffield Childrens Hospital

SC(NHS)FT Reg I D No 1246 Medical Guidelines for Paediatric Medicine



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SC(NHS)FT Reg. I.D. No. 1246 Medical Guidelines for Paediatric Medicine

ANTIBIOTIC DOSES

This guidance does not cover the treatment of line infections, haematology / oncology patients, patients with Tuberculosis,

or patients with Cystic Fibrosis - please refer to separate guidelines. SC(NHS)FT Implemented March 2018, Review March 2021 (do not use after this date) Page 1 of 10 f

2.4 ANTIBIOTIC DOSES

Antibiotic

Type of infection

Dose

Method of

administration

Length of treatment

Comments

Amoxicillin

Neonatal meningitis

Age 0-3 months

< 7 days 100mg/kg 12 hourly

7-28 days 100mg/kg 8 hourly

>1 month 100mg/kg 6 hourly

Slow IV infusion

over 30 minutes

21 days

Avail. oral preparations:

250mg capsules

125mg in 5ml

suspension

250mg in 5ml

suspension

Mild Pneumonia

Otitis media

Sinusitis

Cellulitis

Dental abscess

1 month 1 year 125mg three times a day

1- 5 years 250mg three times a day

5-18 years 500mg three times a day

Oral Otitis media : 5-7 days

Sinusitis: 7 days

Dental abscess: 7

days

Benzylpenicillin

Severe cellulitis

Pneumonia

Age < 7days 50mg/kg twice day

7 28 days 50mg/kg three times a day

1 month - 18 years 50mg/kg four times

daily

Slow IV over 30

minutes

Depends on clinical

response

Age 1 month 18

years:

Max 2.4g four times

daily

Cefaclor

Bacterial chest

infection

Age 1month - 1 year 62.5mg three times a

day

Age 1 - 5 years 125mg three times a day

Age > 5 years 250 mg three times a day

Oral

Doses may be doubled

in infections caused by less susceptible organisms

Avail. oral preparations:

250mg & 500mg

capsules

125mg in 5 ml

suspension

250mg in 5 ml

suspension

SC(NHS)FT Reg. I.D. No. 1246 Medical Guidelines for Paediatric Medicine

ANTIBIOTIC DOSES

This guidance does not cover the treatment of line infections, haematology / oncology patients, patients with Tuberculosis,

or patients with Cystic Fibrosis - please refer to separate guidelines. SC(NHS)FT Implemented March 2018, Review March 2021 (do not use after this date) Page 2 of 10 f

Antibiotic

Type of infection

Dose

Method of

administration

Length of treatment

Comments

Cefalexin

UTI < 7days 25mg/kg (max 125mg) twice daily

7-21days 25mg/kg(max 125mg) three times

a day

21-28days 25mg/kg (max 125mg) four

times a day

1 mth 12 yrs 25mg/kg twice daily (Max

1g) OR

1 month 1 year 125mg twice daily

1-5 years 125mg -250mg three times a

day

6-12 years 250mg-500mg three times a

day

12-18 years 500mg twice daily

Oral

7 days

Avail. oral preparations:

250mg & 500mg tablets

125mg in 5 ml

suspension

250mg in 5 ml

suspension

Cefotaxime

Neonatal meningitis,

osteomyelitis & sepsis

Age < 7 days 50 mg/kg twice daily

7-21 days 50mg/kg three times daily

> 21 days 50mg/kg three to four times a day

Slow IV bolus

Refer to Bacterial

Meningitis Guideline in

Medical Guidelines

Maximum adult daily

dose 12g

Emergency treatment:

Initial dose of 100mg/kg

(max dose 2g) may be given as a short infusion

Meningitis

Acute Epiglottitis

Meningococcal sepsis

Osteomyelitis

Age > 1 month 50mg/kg four times

daily

NB: osteomyelitis >3

months, see cefuroxime

Ceftriaxone

Meningitis

Meningococcal

sepsis

Acute epiglottitis

Birth -to 15 day 50mg/kg once daily

Age > 15 days - 11 years (body weight up

to 50kg) 80mg/kg >50kgs or 12-17 years: 4g once daily

IV infusion over

60 minutes in

neonates

IV infusion over

at least

30minutes if > 1

month of age

Refer to Bacterial

Meningitis Guideline in

Medical Guidelines

Max. daily dose 4g

Please note IM

Ceftriaxone is not

recommended to complete the course

SC(NHS)FT Reg. I.D. No. 1246 Medical Guidelines for Paediatric Medicine

ANTIBIOTIC DOSES

This guidance does not cover the treatment of line infections, haematology / oncology patients, patients with Tuberculosis,

or patients with Cystic Fibrosis - please refer to separate guidelines. SC(NHS)FT Implemented March 2018, Review March 2021 (do not use after this date) Page 3 of 10 f

Antibiotic

Type of infection

Dose

Method of

administration

Length of treatment

Comments

Meningitis prophylaxis Adult : 250 mg single dose

IM (Adult

prophylaxis only)

Prophylaxis in pregnant

contacts

Cefuroxime

UTI

Peritonitis

Pneumonia

Orbital &

periorbital cellulitis

Osteomyelitis & septic

arthritis (Age >3 months)

Age < 7days 30 mg/kg twice daily

Age 7 - 20 days 30 mg/kg three times

daily

Age 21-28 days 30 mg/kg four times a day

Age > 1 month 30 mg/kg three times

daily

Do not exceed adult dose (1.5g three times

a day)

Slow IV bolus

Consider 50mg/kg in

osteomyelitis, septic arthritis, severe pneumonia and other severe infections.

Chloramphenicol

Bacterial conjunctivitis

1 drop / application of ointment

4 - 6 times a day

Topical

Continue for 48 hours

after eyes clear

Available preparations:

0.5% eye drops

1% eye ointment

Ciprofloxacin

Meningococcal

prophylaxis

1month 5 years : 125mg single dose

Children 5-12 years (only if able to swallow

tablets): 250mg single dose

Adults and children >12 yrs:

500mg single dose

Oral

Single dose

Ciprofloxacin 250mg

tabs.

250mg in 5ml

Suspension

NB suspension not

normally dispensed for meningitis prophylaxis.

Please see Rifampicin if

liquid preparation needed for prophylaxis

Shigella & Salmonella

Neonate 15mg/kg twice daily

1 month 18 years 20mg/kg (max 750mg)

twice daily Oral

7 days

Severe animal &

human bites in patients allergic to penicillin

Neonate 15mg/kg twice daily

1 month 18 years 20mg/kg (max 750mg)

twice daily

Oral 10 14 days

SC(NHS)FT Reg. I.D. No. 1246 Medical Guidelines for Paediatric Medicine

ANTIBIOTIC DOSES

This guidance does not cover the treatment of line infections, haematology / oncology patients, patients with Tuberculosis,

or patients with Cystic Fibrosis - please refer to separate guidelines. SC(NHS)FT Implemented March 2018, Review March 2021 (do not use after this date) Page 4 of 10 f

Antibiotic

Type of infection

Dose

Method of

administration

Length of treatment

Comments

Clarithromycin

Pneumonia

URTI

Campylobacter

enteritis

Skin infections

Chlamydial

conjunctivitis

Intravenous infusion

1 month 12 years 7.5mg/kg (max 500mg)

twice daily

12-18 years 500mg twice a day

Oral <8kg 7.5mg/kg twice daily

8-11kg 62.5mg twice daily

12-19kg 125mg twice daily

20-29kg 187.5mg twice daily

30-40kg 250mg twice daily

12-18 years 500mg twice daily

IV infusion over

60 mins

Oral

Pertussis 7 days

Pneumonia (atypical)

7 days

Skin infections 7-14

days

Chlamydial

conjunctivitis: 14days

Consider switch to oral

preparation as soon as enteral absorption is satisfactoryquotesdbs_dbs8.pdfusesText_14