Med Chem 535P – Diagnostic Medicinal Chemistry Hematology
recognized by a T-lymphocyte, which is then activated C Lymphocytes (Lymphs) Normal Range: 20 – 40 Lymphocytes make up the second major group of leukocytes and are primarily involved in immune reactions They form the cellular components of the adaptive immune system These cells are non-phagocytic They are difficult to differentiate
Chapter 2 Cells and Organs of the Immune System Hematopoiesis
- Somewhat phagocytic; Comprise 1 - 3 of leukocytes - Thought to be important in defense against invading parasites and worms (helminths) - Worm infections are often accompanied by eosinophilia - Release eosinophilic granules that damage parasites Basophils: - Comprise
Immunology Lecture- 1 - KSU
lymph nodes, lymphocyte proliferation, etc ) Bone marrow, the soft tissue on the hollow center of bones, is the ultimate source of all blood cells, including white blood cells destined to become immune cells
CARDIOVASCULAR SYSTEM: BLOOD
Components • Cardiovascular system –Heart –Blood vessels –Blood –transport of nutrients, hormones, oxygen, waste, carbon dioxide • Lymphatic system (*)
Leukocytes (White Blood Cells)
Leukocytes (White Blood Cells) Leukocytes are the only formed elements that are complete cells, with nuclei and the usual organelles Accounting for less than 1 of total blood volume, leukocytes are far less numerous than red blood cells On average, there are 4800–10,800 WBCs/μl of blood Leukocytes are crucial to our defense against disease
Ch 20: Blood
Lymphocyte (chapt 21) ~ 20 - 30 of circulating WBCs Relatively small (slightly larger than RBCs, smaller than PMNs) Large round nucleus, not much cytoplasm Mostly found in tissues Types » B lymphs become plasma cells » T lymphs attack directly » NK recognize “lack of self ” Neutrophil Eosinophil Basophil Lymphocyte Monocyte
Chapter 2 Cells and Organs of the Immune Hematopoiesis
- main phagocytic (acute) cell Better than M Φs - ↑ in neutrophils – leukocytosis and infection - recruited to site of infection/inflammation Eosinophils: - Somewhat phagocytic; Comprise 1-3 of leukocytes - Important in defense against invading parasites and worms (helminths) toxic granules
White Blood Cells (WBCs) or Leukocytes
White Blood Cells (WBCs) or Leukocytes Although leukocytes are far less numerous than red blood cells, they are important to body defense against disease On average, there are 4000 to 11 000 WBCs/mm3, and they account for less than 1 percent of total blood volume White blood cells are the only complete cells in blood;
Immunity: innate(non-specific) və acquired (specific
Other cells with phagocytic activity • endothelial cells of blood and lymph vessels, • cells of the pleural and peritoneal membranes, • reticuloendothelial cells of the liver (Kupffer cells), • dendritic cells of the lymph nodes (Langerhans cells), • histocytes, • fibroblasts, etc
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