Burkholderia Type VI Secretion Systems Have Distinct Roles in

Burkholderia mallei is a facultative intracellular pathogen that causes the highly contagious and often fatal , diseaseglanders With its high rate of infectivity via aerosol and recalcitrance towards antibiotics, this pathogen is considered a potential biological threat agent This review

Characterization of Clinically-Attenuated Burkholderia

Background:Burkholderia mallei is an understudied biothreat agent responsible for glanders which can be lethal in humans and animals Research with this pathogen has been hampered in part by constraints of Select Agent regulations for safety reasons Whole genomic sequencing (WGS) is an apt approach to characterize newly discovered or poorly

occurs, known as ‘farcy’ - OIE

Identification of the agent: Smears from fresh material containing B mallei bacteria may reveal Gram-negative nonsporulating, nonencapsulated rods Burkholderia mallei grows aerobically and prefers media that contain glycerol Standard media for isolation of B pseudomallei can be used and selective enrichment techniques have been developed

A Genomic Survey of Positive Selection in Burkholderia

Burkholderia pseudomallei (Bp), the causative agent of the often-fatal disease melioidosis, represents one of the most complex bacterial genomes sequenced to date [1] Comprising two circular chromosomes with a combined length of 7 2 Mb, the Bp genome contains an estimated ,5800 genes involved in a myriad of

Less Is More: Burkholderia pseudomallei and Chronic Melioidosis

also show a striking parallel to Burkholderia mallei, a separate Burkholderiaspecies originally derived from B pseudomallei(11) Tellingly, both the B pseudomallei chronic strains and B mallei demonstrated genomic reduction across the same regions, such as the genes BPSS1096 to BPSS1112 and BPSS1123 to BPSS1203,

SELECT AGENTS FACT SHEET - ABSA International

Bacteria Burkholderia mallei Equines, especially horses and mules; humans are accidental hosts Direct contact with nasal secretion of equines; inhalation of aerosols 1 Chronic pulmonary form with cough, mucopurulent discharge; Farcy 2 A form with multiple abscesses in the skin, subcutaneous tissues and lymphatics 3