Valdoxan - European Medicines Agency
The active substance in Valdoxan, agomelatine, is an antidepressant It works in two ways, by stimulating the MT1 and MT2 receptors and by blocking the 5 -HT 2C receptors in the brain This is thought to lead to increases in the levels of the neurotransmitters dopamine and noradrenaline
Agomelatine - neiglobalcom
agomelatine: a novel antidepressant exploiting synergy between monoaminergic and melatonergic properties CNS Spectrums 2014 ; 19: 207 –12 Stein DJ , Picarel-Blanchot F , Kennedy SH Efficacy of the novel antidepressant agomelatine on anxiety symptoms in major depression Hum Psychopharmacol 2013 ; 28 (2): 151 –9
Efficacy of the Novel Antidepressant Agomelatine on the
Agomelatine is the first melatonergic antidepressant acting as a potent MT 1 /MT 2 receptor agonist with 5-HT 2C receptor antagonist properties 18,19 Both properties con-tribute to the antidepressant activity of agomelatine 20,21 Agomelatine has been shown to resynchronize altered cir-cadian rhythms both in an animal model of depression22
Agomelatine efficacy and acceptability revisited: systematic
Agomelatine is a novel antidepressant drug with narrative, non-systematic reviews making claims of efficacy Aims The present study systematically reviewed published and unpublished evidence of the acute and long-term efficacy and acceptability of agomelatine compared with placebo in the treatment of major depression Method
A novel atypical antidepressant drug: Agomelatine - A review
antidepressant to incorporate a non-monoaminergic mechanism of action This article reviews the significance and pharmacological aspects of a novel atypical antidepressant drug, agomelatine
Guidelines for switching between specific antidepressants
stop agomelatine, then start fluvoxamine* stop agomelatine, then start vortioxetine stop agomelatine, then start SNRI stop agomelatine, then start above drug stop agomelatine, then start reboxetine stop agomelatine, then start above drug at low dose (usually 25 mg)* stop agomelatine, then start clomipramine stop agomelatine, then start moclobemide
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