[PDF] Analysis of synonymous codon usage of transcriptome database



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least half of the human genome

ture termination of transcription and, hence, their insertion in the sense strand is conterselected [5] SINEs and DNA transposons (that have no or weak polyadeny-lation signals [5]) show a much less pronounced strand bias The significance of Wilcoxon tests is indicated (*, P , 5 ; **, P , 1 ) Abbreviations: DNA, DNA



Analysis of synonymous codon usage of transcriptome database

correct initiation and termination codons were remained and sequences contain internal termination codons were eliminated by using SelectCDS script (Meier et al , 2017) In additional, only the sequences longer than 100 amino acids in length were hold for further analysis Finally, 2,626 CDS were left for the downstream codon usage analysis



RelationshipsAmongStopCodonUsageBias,ItsContext,Isochores

downstreamof the stop codon on translation termination EMBORep2:787–793 PesoleG,LiuniS,GrilloG,LicciulliF,MignoneF,GissiC, SacconeC(2002)UTRdbandUTRsite



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Stop-codon read-through arises largely from molecular errors

The stop codon gives the translating ribosome the signal for the termination of peptide synthesis, but occasionally the ribosome goes past the stop codon and continues translat-ing into the otherwise untranslated region of a transcript Stop-codon read-through gen-erates an elongated peptide, which could be beneficial under certain circumstances



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