[PDF] Centre Hospitalier Universitaire Vaudois (CHUV)

1 PERSONAL INFORMATION - CHUV

Head of the Service of Medical Microbiology of the University Hospital (CHUV) Head of a group for research on Intracellular Bacteria (dedicated to Chlamydia &Waddlia research) Head of a group of research on giant viruses (Lausannevirus, Cedratvirus lausannensis) Head of the Laboratories of Clinical Diagnostic Microbiology (RT)

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

The Centre Hospitalier Universitaire Vaudois (CHUV) is one of five Swiss university hospitals Thanks to its collaboration with the Faculty of Biology and Medicine at the University of Lausanne, CHUV is a European leader in medical treatment, medical research and training It serves as a general hospital for the local population as well as a

Professor Michel Gilliet

Impact of a fracture liaison service on patient management

versitaire Vaudois (CHUV), Lausanne, Switzerland Lau-sanne is a city of more than 133 800 people, and is the main city of the state of Vaud, which had a population of 778 251at the end of2016 The CHUV is the biggest pub-lic hospital in the canton of Vaud, and the only university hospital The orthopaedic capacity is 100 beds After de-

Centre Hospitalier Universitaire Vaudois (CHUV)

Centre Hospitalier Universitaire Vaudois (CHUV) Faculté de Biologie et de Médecine de l’Université de Lausanne Quantitative Mass Spectrometry Facility (qMSF) Ion Source Pumps for vacuum Mass Spectrometer I Mass Spectrometer II Liquid (H2O + CH3OH) samples injector pump Analytical Column : separation of drugs or peptides Mass Detection 100

Pulmonary function and radiological features four months

Dec 17, 2020 · Division of Pulmonary Medicine, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland 11 Department of Internal Medicine, University and Hospital of Fribourg, Switzerland 12 Department of Pulmonary medicine, Clinica Luganese Moncucco, Lugano, Switzerland 13

Protocole HDF au CHUV / Dialyse chronique

Protocole HDF au CHUV / Dialyse chronique Indications théoriques et intérêts - Patients avec hypotensions répétées en dialyse1 - Hyperphosphatémies difficilement contrôlables (élimination accrue de 20 à 30 )2, 3

ESPEN endorsed recommendations: Nutritional therapy in major

d Service of Adult Intensive Care Medicine and Burns Centre, University Hospital (CHUV), Lausanne, Switzerland q Expert group of the Société Française d’Anesthésie-Réanimation (SFAR), Société Francophone de Nutrition Clinique (SFNEP), Société de Réanimation de langue Française (SRLF) article info Article history: Received 21

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Faculté de Biologie et de Médecine

to help partners in their research demanding MS technologyto develop the own qMSF Researchto perform routine analyses

Centre Hospitalier Universitaire Vaudois (CHUV)

Faculté de Biologie et de Médecine de l'Université de Lausanne

Quantitative Mass Spectrometry Facility (qMSF)

Ion

Source

Pumps for vacuum

Mass

Spectrometer

I Mass

Spectrometer

II

Liquid

(H 2O + CH 3OH) samples injector pump

Analytical Column :

separation of drugs or peptides

Mass Detection100200300400500600

mass

0276.1

Precursor ion

Ab u n da nc e

100200300400500600

mass

0207.1

Product ion

Ab u n da nc e

Time [min.]

3.7 min

Intensity

Mass 207.1

26 ng/mL

MS chromatogram

What are LC-MS instruments ?

liquid chromatography mass spectrometryidentification or/and quantification with specific softwares

Dr. Bertrand Rochat, PhD, Project Leader,

Head of Quantitative Mass Spectrometry Facility, BH18, CHUV, Rte du Bugnon, CH - 1011 Lausanne

For feasibility and evaluation,

Please,

Dr. Bertrand Rochat, Project Leader,

Head of Quantitative Mass Spectrometry Facility,

Dpt. de Recherche, BH18, CHUV,

CH - 1011 Lausanne

E-mail: bertrand.rochat@chuv.chquadrupoleIon sourcequadrupoles

Q1, Q2 and Q3

At qMSF, we have a Triple Quadrupole

and a Linear Ion Trap MS instruments •Resistance to anti-cancer agents mediated by drug metabolism in cancer cells • Structure elucidation of drug metabolite by the determination of fragmentation pathways• Quantitation of metanephrines in patients' plasma• Quantification of caspofungin in patients' plasma • Quantification of neuropeptide Y in plasma (in progress) • Characterization of fatty acids, leukotriene arachidonic acid in cellular extracts (in progress) • Quantification of protease inhibitors in patients' plasma • Quantification of imatinib in patients' plasma and WBC • Identification of peptide degradation by-products •Etc ...

Some examples of expertise at qMSF

to help all researchers who need mass spectrometers to develop the own qMSF research ... to perform routine analyses ...fundamental, biomedical, and clinical research

The Goals of are :

What can a Mass Spec

do for YOU ?? Mass spectrometers are the best instruments to quantitate and identify drugs, endogenous molecules and proteins.

At mass spectrometers can :

quantitate drugs, endogenous molecules and proteins identify drug metabolites or proteins perform many other investigations qMSF is a platform of mass spectrometer instruments of the Faculté de Biologie et de Médecineat CHUV. The platform is open to anyone who needs this technology. The Project Leader in charge of this facility is Dr. Bertrand Rochat bertrand.rochat@chuv.ch ... in ... O N N O m/z : 276.1 207.1 collision H++ H

Some partners ...

•Pharmacologie Cliniqueat CHUV •Maladie Infectieuseat CHUV • Xigen SA at Lausanne •Centre Intégratif de Génomiqueat UNILausanne •Etc...quotesdbs_dbs7.pdfusesText_5