Biosynthesis of steroid hormones Synthesis and hydroxylation
(Cholecalciferol) (25-Hydroxycholecalciferol) (1α,25-Dihydroxycholecalciferol) A CALCIOTROPIC STEROID HORMONE 20 -30 days The concentration of calcidiol in blood plasma informs of the body calciol saturation Seasonal variations are observed 25 -Hydroxylation of calcidiol is inhibited by the high concentrations of calcidiol and calcitriol
REPRODUCTION
calcitriol, (1α,25-dihydroxycholecalciferol), which is the most bioactive vitamin D isoform Circulating calcidiol can also be converted to calcitriol in other cell types and tissues, including the placenta (Shin et al 2010) Inactivation of vitamin D molecules results from the CYP24A1 hydroxylase, which converts both calcidiol
CYP27A1 expression in gilthead sea bream (Sparus auratus, L
produces 24R,25-dihydroxycholecalciferol It is noteworthy that, CYP24 also uses calcitriol to produce 1a,24R,25-trihydroxycholecalciferol, the first product in the C-24 oxidation pathway responsible for degradation of calcitriol Comparatively little is known in teleosts concerning ‘vitamin D 3 physiology’ Indeed, classical genome-mediated
維生素D與人體健康 - tsimorgtw
物技術資訊中心 (National Center for Biotechnology Information，NCBI) 所提供的PubChem資料庫19， 目前知道的維生素D有維生素D 2至D 7，維生素D 1 因被證實為混合物已較不常使用，維生素D 2及D 3 為人體內主要的維生素D，常見不同形式的維生 素D 2及D 3列於表一1,20,21。維生素D的
Publications for Christian Girgis 2020 2019 2015
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Article 1,25-(OH) D-24 Hydroxylase (CYP24A1) Deficiency as a
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