Colistin® - Colistimethate sodium for injection and
The elimination of colistimethate sodium following inhalation has not been studied Colistimethate sodium kinetics appear to be similar in children and adults, including the elderly, provided renal function is normal Limited data are available on use in neonates which suggest kinetics are similar to children and adults but the possibility of
COLISTIMETHATE FOR INJECTION, USP
Each vial contains colistimethate sodium or pentasodium colistinmethanesulfonate (150 mg colistin base activity) as a white to slightly yellow lyophilized cake The sodium content is approxi-mately 0 07 mg (0 003 mEq) of sodium per milligram of Colistin Colistimethate sodium is a polypeptide antibiotic with an approximate molecular weight of 1750
Coly-Mycin M Parenteral (Colistimethate for Injection, USP)
Colistimethate sodium was not teratogenic in rats at 4 15 or 9 3 mg/kg These doses are 0 13 and 0 30 times the maximum daily human dose based on mg/m 2 There are no adequate and well-controlled studies in pregnant women Since colistimethate sodium is transferred across the placental barrier in humans, it should be used
(COLISTIMETHATE SODIUM) NAME OF THE MEDICINE 2 QUALITATIVE
mg of colistimethate sodium Colistimethate sodium is a polypeptide antibiotic It is prepared from colistin base by the action of formaldehyde and sodium hydrogen sulphite Colistimethate sodium (the active pharmaceutical ingredient) is very soluble in water, slightly soluble in alcohol, and practically insoluble in acetone, chloroform and ether
Colistimethate Sodium PK/PD - UCLA Health
May 08, 2017 · Colistimethate Sodium Overview: The polymyxins, including colistin and polymyxin B, are used for the treatment of multi-drug resistant gram negative bacterial infections Colistin is available as the inactive prodrug, colistimethate sodium (CMS) PK/PD: Colistin demonstrates concentration-dependent bactericidal activity and its therapeutic
Colistimethate Sodium (Intravenous) Monograph - Paediatric
Colistimethate sodium is a bactericidal polymyxin antibacterial (also known as polymixin E) – It is a pro-drug of colistin base lipopolysaccharides in the bacterial cell wall (1-4) Colistimethate sodium is a High Risk Medicine INDICATIONS AND RESTRICTIONS Colistimethate sodium is used in the treatment of multi-drug
Nebulized Colistimethate (Coly-Mycin ) or Colistin
1 Add enough sodium chloride (0 9 ) solution to the nebulizer cup to total about 3 mL in the cup Adding the sodium chloride to the colistimethate in the nebulizer cup makes it easier to nebulize the medicine without coughing If your pharmacy supplies you with sodium chloride 0 9 3 mL vials: • Add about 1/3 (or 1 mL) of the
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