[PDF] Cholestol Gold TM - Sheely Chiro



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Laboratory Procedure Manual

(1) Fasting Recent food intake exerts little effect on plasma total cholesterol concentration Plasma triglycerides, however, increase in postprandial plasma to an extent that is related to the fasting triglyceride levels and the amount of fat intake This is due to the appearance of chylomicrons in the circulation after a fat-containing meal



High Cholesterol (Dyslipidemia) - National Jewish Health

Triglyceride is a form of fat made in the body Elevated triglycerides can be due to overweight/obesity, physical inactivity, cigarette smoking, excess alcohol consumption and a diet very high in carbohydrates (60 percent of total calories or more) Many times, people with diabetes have high triglycerides when their blood sugar is not well



TRIGLYCERIDES - Beckman Coulter

total precision is less than 5 CV Assays of serum pools were performed and the data reduced following CLSI guidelines above N = 80 Within run Total Mean, mg/dL SD CV SD CV 89 4 0 57 0 64 1 48 1 65 191 0 95 0 49 2 69 1 41 442 2 28 0 51 6 45 1 46 Method Comparison15 Patient samples were used to compare this Triglyceride Reagent



CHOLESTEROL - Beckman Coulter

Total serum cholesterol analysis has proven useful in the diagnosis of hyperlipoproteinemia, atherosclerosis, hepatic and thyroid diseases 1 Total and HDL cholesterols, in conjunction with a triglyceride determination, provide valuable information for the prediction of coronary heart disease 2



High Blood Cholesterol What you need to know

Losing weight can help lower your LDL and total cholesterol levels, as well as raise your HDL and lower your triglyceride levels Physical Activity Not being physically active is a risk factor for heart disease Regular physical activity can help lower LDL (bad) cholesterol and raise HDL (good) cholesterol levels It also helps you lose weight



Cholestol Gold TM - Sheely Chiro

Cholestol Gold is a much better and safer option for individuals with moderately elevated total cholesterol, LDL, and trig lyceride levels When combined with a diet low in saturated fat and cholesterol and exercise, Cholestol Gold is proven to be extremely effective at maintaining healthy blood lipid levels Cholesterol comes from two sources



NS BIO-TEC

Cholesterol +O2 Cholest-4-ene-3-one+H2O2 2 H2O2+ 4-AAP + Phenol Quinoneimine dye + 4 H2O The intensity of the color produced is directly proportional to cholesterol concentration It is determined by measuring the increase in absorbance at 500 – 550 nm EXPECTED VALUES Risk classification Total Cholesterol Desirable



Determination of Cholesterol Level in Human Serum

2 Reagents and Apparatus 1 Cholesterol buffer solution (Cholesterol kit, 100 mL) - phenol 132 mg, NaH 2 PO 4 0 78g, NaH 2 PO 4 0 71 g 2 Enzyme reagent



CholestePure Plus - Pure Encapsulations

meals or snacks for a daily total intake of 2 g as part of a diet low in saturated fat and cholesterol may reduce the risk of heart disease One serving of CholestePure Plus supplies 0 5 g of phytosterols Scientific evidence establishes that phytosterols in the diet help to lower blood total and LDL cholesterol levels

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Cholestol Gold

INTRODUCTION:

Heart attacks and stroke cause more than 930,000 deaths per year in the United States alone. Cardiovascular disease is the number one cause of death in the U.S., accounting for 40% of all deaths. Reducing serum cholesterol levels is an effective strategy for preventing cardiovascu- lar disease. According to the National Health and Nutrition Examination Survey III, only 6.6% of Americans with elevated cholesterol levels are using drug therapy and only 4% are using nutritional therapy to reduce cholesterol. Statin drugs are the most widely used drugs to reduce cholesterol, however they produce serious side effects. Statins can cause rhabdomyolysis, a deadly condition where dying muscle cells overwhelm the kidneys causing failure. Long term exposure to statins also substantially increases the risks of polyneuropathy. Statin drugs lower cholesterol levels by inhibiting the biosynthesis of the enzyme HMG-CoA reductase in the liver. This enzyme is responsible for the production of cholesterol in the liver.

This mechanism of action not only is potentially harmful to the liver but CoQ10 also shares the same biosynthetic pathway. Therefore one

unfortunate consequence of consuming a statin drug is the unintentional inhibition of CoQ10 synthesis, an indispensable nutrient for cardiac

function.

The long-term consequences of taking statin drugs are not known, however the side effects of muscle pain, liver problems, cancer, nerve

damage and depletion of CoQ10 are. For these reasons statins should be reserved for individuals with chronically high cholesterol levels who

are at serious risk.

Cholestol Gold is a much better and safer option for individuals with moderately elevated total cholesterol, LDL, and triglyceride levels.

When combined with a diet low in saturated fat and cholesterol and exercise, Cholestol Gold is proven to be extremely effective at maintaining

healthy blood lipid levels.

Cholesterol comes from two sources. About 20-30% comes from food and about 70-80% is made in the liver. Cholestol Gold's

dual mechanism of action lowers total cholesterol, LDL and triglycerides at both sources. Cholestol Gold blocks the absorption of

cholesterol in the diet and safely reduces the amount of cholesterol synthesized by the liver.ACTIVES:

Sytrinol

TM - Lowers cholesterol produced in the liver Sytrinol is a patented proprietary formula derived from natural citrus polymethoxylated flavones and palm toctrienols. This combination results in a synergistic effect shown by several clinical studies to produce the following results:

Average Results

Total cholesterol reduction 25%

LDL cholesterol reduction 23%

Triglyceride reduction 28%

HDL increase 3%

LDL/HDL reduction 24%

Sytrinol works by a natural breakdown of HMG CoA reductase by increasing the rate at which the enzyme molecules degrade. This natural process reduces total cholesterol without any of the side effects associated with statins. Since this process in no way interferes with the biosynthetic pathway that synthesizes CoQ10, the effective- ness of Sytrinol does not lower CoQ10 levels like statins. Research shows that Sytrinol is more effective among individuals with a genetic predisposition to hypercholesterolemia, because it alters the level of cholesterol produced.Sytrinol's Cardio-Protective Benefits: Lowers total cholesterol- the tocotrienols in Sytrinol inhibits HMG CoA reductase, the liver enzyme responsible for endogenous synthesis of cholesterol. Lowers LDL (bad) cholesterol- the polymethoxylated flavones in Sytrinol decrease apoliprotein B, the structural protein needed for endogenous synthesis of LDL cholesterol. Lowers trigylcerides- the polymethoxylated flavones in Sytrinol (tangeritin and nobiletin) decrease diacylglycerol acetyl transferase, a liver enzyme needed for endogenous synthesis of triglycerides. Reduces inflammation- Inflammation is a known risk factor in cardiovascular disease. The polymethoxylated flavones in Sytrinol have been shown through numerous studies to be effective at reducing inflammation and more than likely reduces C-reactive protein, a reliable marker and predictor of sudden heart attack. Powerful anti-oxidant- the tocotrienols in Sytrinol have 40-60 times greater anti-oxidant properties than vitamin E. Plus the polymethoxylated flavones are also powerful anti-oxidants.120 capsules per bottle

Three capsules provide:

Sytrinol

TM

150 mg

(Proprietary extract of polymethoxylated flavones and tocotrienols from citrus and palm fruits)

Phytosterols (from soy) 400 mg

Guggulipid®*Extract

(std. extract, resin)

225 mg

Inositol Hexaniancinate 112.5 mg

Vitamin B6 12.5 mg

Folic Acid 250 mcg

Vitamin B12 250 mcgOther ingredients: Gelatin (capsule), calcium carbonate, cellulose, silicaand vegetable stearate.*Guggulipid® is a registered trademark of the Sabinsa Corporation.

TM These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

CLINICAL INDICATIONS:

High Cholesterol, LDL and Triglyceride Levels

SUGGESTED USAGE:

As a dietary supplement, adults take 3 capsules twice daily with meals, or as directed by physician.

CONTRAINDICATIONS: Pregnancy

DRUG INTERACTIONS: None known

REFERENCES:

Tripathi YB, et al. "Thyroid stimulating action of Z-guggulsterone obtained from

Commiphora mukul." Planta Med. 1984; 1:78-80.

Singh RB, et al. "Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy." English, Jim. "Novel Dietary Supplement Shows Dramatic Effects in Lowering Cholesterol, LDL, and Trigylcerides." Life Extension Magazine. Nov. 2004. "Treatment of dyslipidemia in high-risk patients: too little, too late." Int J Clin Pract

Suppl. 2002 Jul; (130):15-9.

"Serum total cholesterol concentrations and awareness, treatment, and control of hypercholesterolemia among US adults: findings from the National Health and Nutrition Examination Survey, 1999 to 2000." Circulation. 2003 May 6; 107(17): 2185-9. "Contemporary awareness and understanding of cholesterol as a risk factor: results of an American Heart Association national survey." Arch Intern Med. 2003 Jul 14;

163(13): 1597-600.

"Use of nutritional supplements for the prevention and treatment of hypercholes- terolemia." Nutrition. 2003 May; 19(5): 415-8. Staack, Richard F. PhD. MBA. "Sytrinol: A Natural Solution for Lowering

Cholesterol"

Hicks, Kevin and Robert Moreau. "Phytosterols and Phytostanols: Functional Food Cholesterol Busters." Food Technology. Vol. 55, No1. January 2001. 63-67. "What are Phytosterols?" www.forbesmedi.com/s/Phytosterols.asp Lichtenstein et.al. "Stanol/Sterol Ester- Containing Foods and Blood Cholesterol

Levels" Circulation. 2001; 103:1177.1.

2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. Guggulipid - Four published clinical trials (two were placebo controlled double blind) using standardized gum guggul on hundreds of patients with hyperlipidemia had the following average results:

Total cholesterol Ave. reduction 15%

LDL cholesterol Ave. reduction 17%

Triglycerides Ave. reduction 24%

HDL cholesterol Ave. increase 14%

Experiments indicate that guggulipid lowers cholesterol by inhibiting the enzyme HMG-CoA reductase in the liver from producing cholesterol. It aids in weight loss by raising the body temperature a few degrees, resulting in thermogenesis (fat burning for energy). Studies show that the sterols in the guggulipid inhibit platelet aggregation preventing thrombosis. Phytosterols- block the absorption of cholesterol in the diet Phytosterols come from plants such as rice bran, wheat germ, corn oils and soybeans. Their molecular structure is so similar to that of cholesterol that phytosterols compete with cholesterol for absorption in the small intestine. However phytosterols are poorly absorbed at a rate of 1/10 th to that of cholesterol. This ties up the absorption pathways in the small intestine for an extended period of time, which makes the blocking process very effective. Phytosterols also inhibit the reabsorption of cholesterol from bile acids in the digestive process, reducing the amount of cholesterol entering the bloodstream. The result is that both phytosterols and dietary cholesterol end up excreted in waste matter. Phytosterols may reduce the risk of heart disease by lowering total and LDL cholesterol. Phytosterols do not affect HDL or triglyceride levels. Much scientific research is available that documents phytosterols ability to block the absorption of cholesterol and consequently reduce both total and LDL cholesterol levels. These studies date back to the 1950's. More than 20 clinical studies have been recently reviewed by the FDA. These studies show that phytosterols lower total and LDL cholesterol by 10-15%. In addition, these studies demonstrated phy- tosterols effectiveness on individuals with normolipidimic and dyslipidimic levels including those on statin or other lipid lowering agents. A recent study confirmed that patients already taking statin drugs could reduce their LDL cholesterol levels by an additional 10% by including phytosterols in their diets.

FDA Allowed Health Claim:

Dietary supplements containing at least 400 mg. per serving of plant sterols, taken twice a day with meals for a daily total intake of at least 800 mg. as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease. A serving of Cholestol Gold supplies 400 mg. of plant sterols.

Enlarged prostate

The phytosterol beta sitosterol has been used successfully for over 20 years in the treatment of benign prostatic hyperplasia (BPH). The BPH symptoms of reduced urinary flow and painful, burning urination were relieved in various studies using the phytosterol beta sitosterol. Niacin - is the only supplement that's been proven in tests as rigorous as those for a prescription drug to lower choles- terol. A study published in the Annals of Internal Medicine comparing niacin with the cholesterol lowering drug lovastatin on 136 patients with high LDL cholesterol over a 26 week period showed the following results:

Niacin Lovastatin

LDL cholesterol reduction 23% 32% HDL cholesterol increase 33% 7% Lp(a) Lipoprotein reduction 35% 0% Inositol Hexaniacinate is a special form of niacin com- posed of six nicotinic acid molecules bound to and surround- ing one molecule of inositol. It has been used in Europe for over 30 years to lower cholesterol and improve blood flow. Inositol hexaniacinate exerts the benefits of niacin without flushing or other side effects.

Cholestol Gold continued...

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