Lipid Biosynthesis - Marquette University
Lipid Biosynthesis Objectives: I Describe how excess carbohydrate and/or amino acid consumption leads to fatty acid and triacylglycerol production II What is the precursor of fatty acid biosynthesis (lipogenesis)? A Where is it generated? B How is it transported to the site of fatty acid biosynthesis? C
An Emerging Role of mTOR in Lipid Biosynthesis
Biosynthesis Mathieu Laplante1,2 and David M Sabatini1,2,3,* Lipid biosynthesis is essential for the maintenance of cellularhomeostasis Thelipidsproducedbycells(glycero-lipids,fattyacids,phospholipids,cholesterol,andsphingo-lipids) are used as an energy source/reserve, as building blocks for membrane biosynthesis, as precursor mole-
ANSC/NUTR 618 Lipids & Lipid Metabolism Fatty Acid Synthesis
II Substrates for fatty acid biosynthesis A Glucose All species can utilize glucose to some extent 1 Nonruminants (rats, pigs, fish, humans) a Glucose is a major nutrient absorbed from the small intestine b Glucose also is essential for lipogenesis from acetate to provide G3P and NADPH (via the pentose cycle) 2 Ruminants (sheep
Inhibiting both proline biosynthesis and lipogenesis
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth --Metabolic reprogramming under hypoxia Authors Miao Liu*, Yuanyuan Wang*, Chuanzhen Yang*, Yuxia Ruan*, Changsen Bai, Qiaoyun Chu, Yanfen Cui,
BIOSYNTHESE DES LIPIDES ( LIPOGENESE )
1 cours de metabolisme chapitre 12 pr c zinsou biosynthese des lipides ( lipogenese ) 1 - introduction 2 - transfert du radical acetyle de la mitochondrie dans le cytosol
de novo Liver Adipose tissue young
Lipogenesis = fatty acid or triacylglycerol synthesis a From preformed fatty acids (from diet or de novo fatty acid synthesis) b Requires source of carbon for glycerol backbone B Tissue sites of de novo fatty acid biosynthesis 1 Liver In birds, fish, humans, and rodents In these species, lipids must be
BIOSYNTHESE DES LIPIDES ( LIPOGENESE )
1 BIOSYNTHESE DES LIPIDES ( LIPOGENESE ) Chapitre 12 Pr C ZINSOI OBJECTIFS De l’enseignant • Présenter la synthèse des lipides (lipogenèse) comme un processus d’anabolisme ou de
Mitochondria as biosynthetic factories for cancer proliferation
glucose-mediated biosynthesis under these conditions through extramitochondrial pathways, scavenging acet-ate [31,32], unsaturated lipids [8,33], or proteins [34] when required Therefore, the relative importance of glucose-driven biosynthesis through mitochondrial path-ways may be tumor specific Alternatively, there may be
2 Biosynthèse des Lipides
Introduction • La biosynthèse des acides gras et des lipides répond à deux impératifs dans la cellule : – fourniture des acides gras nécessaires à la synthèse des lipides de structure ;
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