Interpretation of Hepatitis B Serologic Test Results
immunity from hepatitis B virus infection Anti-HBs also develops in a person who has been successfully vaccinated against hepatitis B Total hepatitis B core antibody (anti-HBc): Appears at the onset of symptoms in acute hepatitis B and persists for life The presence of anti-HBc indicates previous or ongoing infection with hepatitis B virus in an
Interpretation of Hepatitis B serology - Brant Health Unit
Indicates either acute Hepatitis B infection or, more often, a carrier of Hepatitis B These individuals are infectious to others This is the test that should be ordered for prenatal screening Babies born to mothers with HBsAg require Hepatitis B Immune Globulin (HBIG) and Hepatitis B vaccine at birth
Hepatitis B - virology
Hepatitis B serological markers • Hepatitis B surface antigen (HBsAg) • This is a protein on the surface of the hepatitis B virus (HBV); it can be detected in the serum during acute or chronic HBV infection • The presence of HBsAg indicates that the person has hepatitis B infection • HBsAg is the antigen used to make hepatitis B vaccine
Hepatitis B Serology
Hepatitis B e antibody (HBeAb or anti-HBe): Produced by the immune system temporarily during acute HBV infection or consistently during or after a burst in viral replication Spontaneous conversion from e antigen to e antibody (a change known as seroconversion) is a
Hepatitis B serology - RACGP
The diagnosis of hepatitis B virus (HBV) infection is established through serological testing The diagnostic panel for hepatitis B serology – allowing determination of susceptibility, active infection, or immunity through vaccination or past infection – includes testing for: • hepatitis B surface antigen (HBsAg)
PRATIE RATIONAL TESTING Ordering and interpreting hepatitis B
Interpretation of hepatitis B virus serology performed at initial testing Result Interpretation HBsAg Positive Acute hepatitis B infection: usually noticeable increases in serum alanine aminotransferase and aspartate aminotransferase levels Infection likely to resolve spontaneously in >95 of adults Occasionally, patients with a
Interpretation of Viral Hepatitis Serology
1 Friedman, L (2015) Liver, biliary tract, & pancreas disorders Current Medical Diagnosis and Treatment (54th ed ) McGraw Hill 2 Hepatitis Web Study
Viral Hepatitis Serologic Profiles - MayoClinicLabscom
Interpretation 1 HBsAg 2 Anti-HBs 3 Anti-HBc (total) 4 Anti-HBc (IgM only) 5a HBeAg 5b Anti-HBe 8 Anti-HAV (IgG only) 9 Anti-HAV (IgM only) 10 Anti-HCV Acute, enteric exposure + Acute hepatitis A - Possible hepatitis E* Acute, non-enteric or type unknown - - + - Acute hepatitis A + + - - Acute hepatitis B** - + Acute or chronic hepatitis C with
Diagnostic virologiques des hépatites virales B et C
Smith B D et al JID 2011 • Etude américaine sur la performance de trois tests rapides VHC (Chembio, Orasure= Oraquick, MedMira) sur sérum de 1083 personnes à risque Excellente spécificité pour les trois tests Oraquick ayant une meilleure sensibilité que Chembio et MedMira FN = individus faussement négatifs
Stratégies de dépistage biologique des hépatites virales B et C
B aiguë récente avant apparition des Ac anti-HBc source d’une perte de chance potentielle : la personne se croira à tort protégée contre le virus et ignorera son hépatite B aiguë et son risque de transmission du virus Or, 5 à 10 des cas risquent d’évoluer vers une hépatite B chronique qui, si elle
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Interpretation of Hepatitis B Serologic Test Results Hepatitis B serologic testing involves measurement of several hepatitis B virus (HBV)-specifi c antigens and antibodies. Different serologic markers" or combinations of markers are used to identify different phases of HBV infection and to determine whether a patient has acute or chronic HBV infection, is immune to HBV as a result of prior infection or vaccination, or
is susceptible to infection.Hepatitis B surface antigen (HBsAg): A protein on the surface of hepatitis B virus; it can be detected in high levels in serum during acute or chronic hepatitis B virus infection. The presence of HBsAg indicates that the person is infectious. The body normally produces antibodies to HBsAg as part of the normal immune response to infection. HBsAg is the antigen used to make hepatitis B vaccine.
Hepatitis B surface
antibody (anti-HBs):The presence of anti-HBs
is generally interpreted as indicating recovery and immunity from hepatitis B virus infection. Anti-HBs also develops in a person who has been successfully vaccinated against hepatitis B.Total hepatitis B core
antibody (anti-HBc):Appears at the onset
of symptoms in acute hepatitis B and persists for life. The presence of anti-HBc indicates previous or ongoing infection with hepatitis B virus in an undefi ned time frame.IgM antibody to hepatitis B
core antigen (IgM anti-HBc):Positivity indicates recent
infection with hepatitis B virus ( <6 mos). Its presence indicates acute infection.TestsResults Interpretation
HBsAgnegative Susceptible
anti-HBc negative anti-HBs negative HBsAg negative Immune due to natural infection anti-HBc positive anti-HBs positive HBsAg negative Immune due to hepatitis B vaccination anti-HBc negative anti-HBs positive HBsAg positive Acutely infected anti-HBc positiveIgM anti-HBc
positive anti-HBs negative HBsAg positive Chronically infected anti-HBc positiveIgM anti-HBc
negative anti-HBs negative HBsAg negative Interpretation unclear; four possibilities: anti-HBc positive1. Resolved infection (most common) anti-HBsnegative2. False-positive anti-HBc, thus susceptible3. Low level" chronic infection4. Resolving acute infection