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*Institut de Ge´ne´tique et de Biologie Mole´culaire et Cellulaire, B P 10142, 67404 Illkirch-Strasbourg, France; and §Centre for Reproductive Medicine, University Hospital, Dutch-Speaking Brussels Free University, Laarbeeklaan 101, B-1090 Brussels, Belgium

doi:101038/nature04209 LETTERS

02115, USA 3Unite´ de Recherche en Biologie Mole´culaire, Faculte´s Notre-Dame de la Paix, 61 Rue de Bruxelles, 5000 Namur, Belgium 4Howard Hughes Medical Institute, and Departments of Pediatrics, Neurology, Neuroscience, and Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA 5 Arcbay,

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