Prostaglandins and related compounds: the eicosanoids
Prostaglandin effects are usually manifested locally around the site of prostaglandin synthesis (paracrine) and their actions are multiple and variable (stimulatory or inhibitory) depending on tissue type and the nature of the receptors with which they interact To date eight prostanoid receptors have been cloned and characterized Note
THE PROSTAGLANDINS: FROM THE LABORATORY TO THE CLINIC
prostaglandin field By that time many pharmaceutical industries had become interested in the field and large synthetic programmes to synthesize prostaglandin analogues were started These synthetic efforts were in part guided by the knowledge of the metabolism of prostaglandins accumulated in Stockholm More than 5000
Prostaglandin E2 (P0409) - Product Information Sheet
Prostaglandin E2 Cell Culture Tested Product Number P 0409 Storage Temperature -0 °C Product Description Molecular Formula: C20H32O5 Molecular Weight: 352 5 CAS Number: 363-24-6 Melting Point: 66-68 °C1 Critical Micelle Concentration: 5 mg/ml1 Synonym: PGE2 Prostaglandin E2 is a signaling molecule produced by activated platelets
Prostaglandin Nomenclature
Prostaglandin Biosynthesis Das, S et al Chem Rev 2007, 107, 3286–3337 Rouzer, C A ; Marnett, L J Chem Rev 2003, 103, 2239–2304 Nicolaou, K C ; Sorensen, E J Classics in Total Synthesis; VCH: Weinheim, 1996; p 66 O O CO2H OH PGH2 O R R ω HO PGI2 O O Rω R α TxA2 O Rω R α TxB2 OH HO R α R ω HO HO PGF2α R α R ω O HO
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