Genetic Variation Exercises SNPs and CNVs
CNV Searches 5 Using resequencing data to identify regions of copy number variation (CNV) In addition to being useful for variant calling, high throughput sequencing data can be used for determining regions of copy number variation (CNV) All reads in ToxoDB are mapped to the
Communication non violente (CNV) communication bienveillante
5 En CNV, on adopte Le parler « Girafe » : la girafe est le mammifère terrestre qui a le plus gros cœur (pour irriguer son cerveau), elle symbolise ainsi le langage du cœur (en communication non violente initiée par Rosenberg) Elle observe sans juger, elle exprime des sentiments sans en rendre l'autre responsable
LISTE DES BESOINS UNIVERSELS SELON LA COMMUNICATION NONVIOLENTE®
LISTE DES BESOINS UNIVERSELS SELON LA COMMUNICATION NONVIOLENTE® BESOIN D’ORDRE PHYSIQUE Air, lumière Eau, nourriture Mouvements, exercices Repos
GESTION DES CONFLITS ET COMMUNICATION NON VIOLENTE
2 Utiliser la communication non violente CNV de Rosenberg en 4 étapes: La Communication Non Violente A La démarche CNV 1° Observation: observer les faits 2° Dire son ressenti (sentiments par rapports à des faits):comment je me sens par rapport à ce que j'observe
Communiquer de manière non violente en 4 étapes, avec un
référence de la CNV L’objet de cet article est de découvrir les 4 étapes du processus de la Communication Non Violente, appelée CNV Pour rendre cette présentation concrète, je l’ai illustrée d’un exemple: Nous sommes dans le cadre d’une conduite de projet, en entreprise Ce projet est dirigé par un manager, Nicolas
encode exercises v2 - researchgatenet
Exercises for the ENCODE data in the Common Cell CNV to access the track details page 7 Here we will change 3 settings At the top, set Maximum display mode to Pack
IMAGE PROFESSIONNELLE - CNV
Module 1 1 1 Image professionnelle Corrigés AF et exercices CNV 10 Personne A : Je suis déçu de vos ventes J’aurais aimé que vous les doubliez Personne B : Je comprends votre déception, mais nous avons eu très peu de clients à cause des congés d’été NON car la personne B concentre d’abord son attention sur les
Les 4 étapes d’une communication non violente à pratiquer en
Afin de s’entrainer à la CNV, vous aurez besoin de connaitre le vocabulaire et les besoins (et de les enseigner à vos ados) Pour cela, je vous invite à consulter ce PDF mis en ligne par spiralis ca qui contient même les faux-sentiments, ceux qui sonnent plutôt comme des culpabilisations
Global diversity, population stratification, and selection of
specific trends in CNV diversity (22, 23) Although there are many other forms of structural variation (e g , inversions or mo-bile element insertions) in this study, we focused on under-standing the population genetics and normal pattern of copy number variation by deep se-quencing a diverse panel of hu-man genomes 28 Results CNV discovery
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Research Article
In the past decade, genome sequencing has provided in- sights into demography and migration patterns of human populations (1-4), ancient DNA (5-7), de novo mutation rates (8-10), and the relative deleteriousness and frequency of coding mutations (11, 12). Global human diversity, howev- er, has only been partially sampled and the genetic archite c- ture of many populations remains uncharacterized. To date, the majority of human diversity studies have focused on single nucleotide variants (SNVs) although copy number variants (CNVs) have contributed significantly to hominid evolution (13, 14), adaptation and disease (15-18). Much ofthe research into CNV diversity has been performed with SNP microarray and array com-parative genomic hybridization
(aCGH) platforms (19-22), which provide limited resolution. In addition, comparisons of popula- tion CNV diversity with hetero- geneous discovery platforms may lead to spurious population- specific trends in CNV diversity (22, 23). Although there are many other forms of structural variation (e.g., inversions or mo- bile element insertions) in this study, we focused on under- standing the population genetics and normal pattern of copy number variation by deep se- quencing a diverse panel of hu- man genomes.Results
CNV discovery
We sequenced to high coverage a
panel of 236 human genomes representing 125 diverse human populations from across the globe (Fig. 1 and table S2). Se- quencing was performed to a mean genome coverage of 41-fold from libraries prepared using a standard PCR-free protocol on the HiSeq 2000 Illumina se- quencing platform (24). The
panel includes representation from a broad swathe of human diversity, including individuals from across Siberia, the Indian subcontinent, and Oceania. We also analyzed the high-coverage archaic Neanderthal (25) andDenisova (
26) as well as three
ancient human genomes to re- fine the evolutionary origin and timing of CNV differences (24). We applied a read-depth- based digital comparative genomic hybridization (dCGH) approach (13, 24) to discover 14,467 autosomal CNVs and545 X-linked CNVs among individuals relative to the refer-
ence genome (Table 1 and table S1), which we estimate pr o- vides breakpoint resolution to ~210 bp (24). CNV calls were
validated with SNP microarrays and a custom aCGH micro- array that targeted all CNVs identified in 20 randomly se- lected individuals (24). The median CNV size was 7,396 bp with 82.2% of events (n = 12,338) less than 25 kbp (24). CNVs mapping to seg- mental duplications were larger on average (median of 14.4Global diversity, population stratification,
and selection of human copy number variationPeter H. Sudmant,
1Swapan Mallick,
2,3Bradley J. Nelson,
1Fereydoun
Hormozdiari,
1Niklas Krumm,
1John Huddleston,
1,39Bradley P. Coe,
1Carl Baker,
1Susanne Nordenfelt,
2,3Michael Bamshad,
4Lynn B. Jorde,
5Olga L. Posukh,
6,7Hovhannes Sahakyan,
8,9W. Scott Watkins,
10 LevonYepiskoposyan,
9M. Syafiq Abdullah,
11Claudio M. Bravi,
12Cristian
Capelli,
13Tor Hervig,
14Joseph T. S. Wee,
15Chris Tyler-Smith,
16George
van Driem, 17Irene Gallego Romero,
18Aashish R. Jha,
18 SenaKarachanak-Yankova,
19Draga Toncheva,
19David Comas,
20Brenna
Henn, 21Toomas Kivisild,
22Andres Ruiz-Linares,
23Antti Sajantila,
24Ene