BMC Evolutionary Biology BioMed Central
vention [22], intron positions are projected onto the sequence of the human serpin α 1-antitrypsin The phases of introns are indicated by the suffixes a-c, according to their location after the first, second, or third base of the codon in question In this reference system, the two introns of L1 genes map to positions 75c and ~176a (the
Review Article Hereditary Breast Cancer: The Era of New
vention strategies Splicing is an important mechanism during which accurate removal of introns is taking place in pre-mRNA molecules Apart from the classical splice
Pathogenic Abnormal Splicing Due to Intronic Deletions that
vention Despite advances of parallel sequencing, interpre-tation of splice variants remains a great challenge 4 Splicing occurs at the level of pre-mRNA which contains
Using self-determination theory to promote physical activity
vention focused on promoting autonomous forms of exer-cise regulation and intrinsic motivation, or a general health education program (controls) At 12 months, the interven-tion group showed increased weight loss (-7 29 ,) and higher levels of physical activity/exercise (+138 ± 26 min/ day of moderate plus vigorous exercise; +2,049 ± 571
Rotational Thromboelastometry (ROTEM)-Based Coagulation
vention The time required for thawing FFP and cryoprecipitate is typically 30-60 minutes, but less time is needed for platelet concentrates and thawed plasma Factor concentrates, such as fibrinogen concentrate, and recombinant activated factor VII (rFVIIa) can be administered rapidly (10 min) because they
Intrinsic versus Extrinsic Cancer Risks: The Debate Continues
Intrinsic Extrinsic versus Risks: Cancer Continues The Debate Frédéric 1,2,4 Thomas,1,4,* Benjamin 3,4 Roche, and Beata clusions, Ujvari Deciphering cer the relative contribu-tion to of intrinsic (e g , genetic) and extrinsic (e g , life style, environ-mental) riskfactorsincancerdevel-opment is crucial for strategizing cancer prevention The
Comprehensive detection of germline variants by MSK-IMPACT, a
vention in healthy individuals [1–3] The effective management of patients with clinical presentations of cancer predisposition syndromes relies on the accurate, comprehensive and high-throughput clin-ical assays to identify all disease-causing mutations present in the patients Massively parallel next-generation sequen-
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