Nucleophilic substitution and elimination (1) (1)
In a substitution reaction, a atom or group is substituted from a substrate by a atom or group There are three kinds of substitution reaction: Electrophilic substitution reaction, free radical substitution reaction, and nucleophilic substitution reaction However, in this chapter we will focus on nucleophilic substitution reaction
Nucleophilic Substitution & Elimination Chemistry 1
Nucleophilic Substitution & Elimination Chemistry 4 Z:\files\classes\314\314 Special Handouts\314 SN & E Fall 2011 doc Br Br Br We cannot make these yet (1o RX) so they are given allylic - (NBS is more likely reagent, but we only know Br2) You will need to make the starting alkene (E2 reactions) Br Br Br2 hν free radical substitution
Chapter 11: Nucleophilic Substitution and Elimination Walden
Elimination Reactions: Nucleophiles are Lewis bases In the reaction with alkyl halides, they can also promote elimination reactions rather than substitution RCC: _ R X 1° alkyl halide SN2 RCCCH2R RCC: RX HR _ Helimination H RH R 2° alkyl halide Elimination is a competitive reaction with nucleophilic substitution
Nucleophilic Substitution & Elimination Chemistry Beauchamp 1
Nucleophilic Substitution & Elimination Chemistry Beauchamp 2 y:\files\classes\315\315 Handouts\315 Fall 2013\2b 315 SN and E & chem catalog, answers doc Problem 4 - In each of the following pairs of nucleophiles one is a much better nucleophile than its closely related partner Propose a possible explanation
201 Nucleophilic Substitution - La Salle University
Nucleophilic Substitution and Elimination What does the term "nucleophilic substitution" imply? • A nucleophile is an the electron rich species that will react with an electron poor species • A substitution implies that one group replaces another Nucleophilic substitution reactions occur when an electron rich species, the nucleophile,
NUCLEOPHILIC SUBSTITUTION AND ELIMINATION
NUCLEOPHILIC SUBSTITUTION AND ELIMINATION The question is how do we discern when substitution is favored verse elimination? The answer is found partly in how we should think about reactions of alkyl halides The characteristic reaction of alkyl halides (or alkyl tosylates) with a Lewis base is elimination, special conditions are required to promote
Chapitre 9 : substitution nucléophile et -élimination
Exemple : substitution de Cl par HO dans le 1-chlorobutane pour conduire au butan-1-ol Dans ce premier chapitre, consacré aux dérivés monohalogénés ou monohalogénoalcanes, nous étudierons les réactions de substitution nucléophile et les r éactionsd’élimina tion
Î Substitution and Elimination Reactions from fluorine to
Alkyl Halides and Nucleophilic Substitution • In a nucleophilic substitution reaction of R—X, the C—X bond is heterolytically cleaved, and the leaving group departs with the electron pair in that bond, forming X:¯ The more stable the leaving group X:¯, the better able it is to accept an electron pair The Leaving Group Chapter 6 10
Chapter 6 Nucleophilic Substitution
Nucleophilic Substitution In this chapter we re-examine nucleophilic substitution reactions in more detail, paying particular attention to stereochemistry and other details of the reaction mechanism We will look at what makes a good nucleophile and we will examine solvent effects on substitution reactions
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