WOBBLE HYPOTHESIS - Jiwaji University
The Wobble Hypothesis •The first two bases of the codon make normal (canonical) H-bond pairs with the 2nd and 3rd bases of the anticodon •At the remaining position, less stringent rules apply and non-canonical pairing may occur •The rules: first base U can recognize A or G, first base G can
SOS BIOTECHNOLOGY WOBBLE HYPOTHESIS MSc II SEM By Dr Richa
Wobble Base Pairing Hypothesis •The wobble hypothesis provides insight into some aspects of the degeneracy of the code –in many cases, the degenerate codons for a given amino acid differ only in the third base; therefore fewer different tRNAs are needed because a given tRNA can base-pair with several codons –the existence of wobble
Beyond the Wobble: The Rule of Conjugates
a molecular basis for the nature of the observed wobble The wobble hypothesis allows for G U base pairing at the third position of the codon in addition to the usual Watson-Crick G C and A U pairing, laying out a mecha-nism for the realization of the degeneracies An alterna-tive explanation for some of the observed degeneracies
129 Lecture2 2020 - University of California, Davis
Crick proposed the Wobble hypothesis to generalize Holley’s observation: - Interaction between codon and anticodon need to be exact at first two positions - The third interaction can be less restrictive, and can include non standard base-pairing This hypothesis accounts for the degeneracy In the Genetic Code The wobble hypothesis (Crick, 1966)
MODULE 7: GENE, GENOME AND GENE EXPRESSION
According to the Wobble hypothesis, the third position of a codon is often interchangeable For example: GCU codes for alanine and so does GCC tRNA with anticodon CGG can bind to this codon and bring alanine
RESEARCH ARTICLE Open Access Structural basis for
wobble position affect the codon recognition properties of the tRNA and are essential for the accurate and complete reading of the genetic code [2] The wobble hypothesis was proposed by Crick to account for the obser-vation that most organisms code for considerably fewer tRNAs than the number of sense codons, precluding a sim-
Role of taurine in the pathologies of MELAS and MERRF
Wobble hypothesis of MELAS The Wobble hypothesis of MELAS traces the respiratory defects to inefficient decoding of the UUG codon According to the wobble hypothesis, the A3243G mutation interferes with the conjugation of taurine with a wobble position uridine of tRNALeu(UUR), a reaction that stabilizes
MODERN CONCEPT OF GENE - WordPresscom
The wobble hypothesis was proposed by Crick (1965), which states that the first two nitrogenous bases of the triplet codon pair according to set rule, i e , A with U, G with C but the third base has much more freedom of pairing The wobble base permits more than one type of pairing
TRANSCRIPTION, TRANSLATION & THE GENETIC CODE
The Wobble Hypothesis • Theoretically need 61 tRNAs –Actually have: •30-40 in prokaryotes •50 in eukaryotes • Fewer tRNAs than codons • “Relaxed” base pairing allows 1 tRNA to bind multiple codons but still deliver correct amino acid
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WOBBLE HYPOTHESIS
SOS in Biochemistry, Jiwaji University, Gwalior
M.Sc. II Semester (2019-20)
Paper BCH 201: Fundamentals of Molecular Biology (Unit IV)The Adaptor Hypothesis
It postulates that the genetic code is read by molecules that recognize a particular codon and carry the corresponding amino acid.Cloverleaf Secondary Structure of tRNA
Page 1293
Codon Translation by Aminoacyl tRNAs
Each tRNA has an anticodon sequence that allows it to pair with the codon for its cognate amino acid in the mRNA. Because base pairing is involved, the orientation of this interaction will be complementary and antiparallel.The arg-tRNAarg has an anticodon sequence, UCG,
allowing it to pair with the arginine codon CGA. The anticodon sequence in tRNA is antiparallel and complementary to the codon translated in mRNA.Wobble
Many amino acids are specified by more than one codon (redundancy). Frequently, a tRNA can translate more than one of these codons, sparing the cell from making multiple tRNAs to carry the same amino acid.
For instance, the arg-tRNAarg can translate both the CGA and the CGG codons that specify arginine. This phenomenon is known as "Wobble" and can be summarized as follows:
- Correct base pairing is required at the first position of the codon (third of anticodon) and the second position of the codon (second of anticodon).
- The third position of the codon does not always need to be paired with the anticodon (e.g., it is allowed to "wobble" in some cases).
Wobble Hypothesis
This proposal was made by Crick in 1965
Explains the arrangements of synonyms in the genetic code.Or Explain both the response of same tRNA molecule to several codons and pattern of redundancy of the genetic code
JD Watson FHC Crick
As per Wobble Hypothesis
At least 32 tRNAs are required to translate all 61 triplet codons. 1 is used for the initiation codon.