The lipid phosphatase myotubularin is essential for skeletal
A classical KO mouse line with a deleted Mtm1 allele (MTM1 4 line) was obtained by crossing Mtm1 ‘‘floxed’’ mice (MTML3) with a transgenic line carrying the Cre transgene under a cytomegalovirus promoter (CMV-Cre line), followed by selection of mice with exon 4 germline excision (Fig 1 a–c) This deletion
T-tubule disorganization and defective excitation-contraction
(F) Percentage of tubules per Z-line in myofibers of 2-week-old mice (P 0 001) Data were obtained from n 16 TA muscle fibers of four WT and four KO mice at both 5 and 2 weeks of age Downloaded at Microsoft Corporation on March 9, 2020 18764 www pnas orgcgidoi10 1073pnas 0900705106 Al-Qusairi et al
AAV-mediated intramuscular delivery of myotubularin corrects
specific mutant line (Mtm1/HSA ¼ mKO) to avoid an immunological reaction against the transgene The tibialis anterior (TA) muscle of 4 week-old muscle-specific knockout (mKO) mice was selected for rAAV vector injection, a widely used muscle for gene therapy experiments, because weakness was already present in hindlimbs at this age (animals
PtdIns5P regulation through evolution: roles in membrane
cell line enhances both ATP production and insulin secretion PX domain: phox homology domain This domain is named for its presence in the NADPH oxidase p40phox and p47phox subunits It is a phosphoinositide-binding module that is composed of 120 amino acids that are found in diverse eukaryotic proteins
Learn JavaScript - Yola
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A survey of Penicillium brevicompactum P bialowiezense from
A survey of Penicillium brevicompactum and P bialowiezense from indoor environments, with commentary on the taxonomy of the P brevicompactum group1 James A Scott, Bess Wong, Richard C Summerbell, and Wendy A Untereiner
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Start line Wind Before the start, leeward boats can always “luff-up” windward boats regardless of how the overlap was created because any course is “proper” before the signal (Rule 17 does not constrain them) I don’t have mark-room at the start and I am the windward keep-clear boat Too bad for me I’ll do a 360 ROW boat always
Having a “Cool” Cat - The Curb
Having a “Cool” Cat Now that I’m older, having a fast car is not as important to me as having a comfortable car When the car is comfortable, the Mrs doesn’t mind going places in it like car events and such in the summer
UVC-Induced Stress Granules in Mammalian Cells
irradiated at 30 J/m2 (Figure 1C), in line with the fact that these cells went into an apoptotic process as they left their substrates (see above) Thus, the minimal dose (10 J/m2) of UVC that induces formation of granules in a high number of cells correlates with cell cycle arrest Intriguing enough, while the number of SGs decreases steadily
welcome mail series
Mailer Type: HTML Subject Line: If you have a child, DO NOT open this email Time of release: 10 30 AM Daily The subject line is specifically chosen to entice the non-transacted-newly registrants to open and respond to the mailer Also a deeper insight into the categories promoted are included starting from this campaign
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