Biopharmaceutics and pharmacokinetics dm brahmankar pdf

To achieve the desired therapeutic objective, the drug product must deliver theactive drug at an optimal rate and amount.
By proper biopharmaceutic design,the rate and extent of drug absorption (also called as bioavailability) or thesystemic delivery of drug to the body can be varied from rapid and complete .

Biopharmaceutics is defined as the study o f factors influencing the rate and amount o f drug that reaches the systemic circulation and the useo f this information to optimize the therapeutic efficacy o f the drug products.
The process o f movement o f drug from its site o f administration tothe systemic circulation is called as absorption.

Simply speaking, pharmacokinetics is thekinetics of ADMEorKADME.
The use of pharmacokinetic principles in optimising the drug dosage to suit individual patient needs and achieving maximum therapeutic utility is called as clinical pharmacokinetics.

It is characterized by the concentration of drug at the site of action and itsrelation to the magnitude o f effects observed.
Simply speaking, pharmacodynamics deals with what the drug does to the body in contrastto pharmacokinetics which is a study o f what the body does to the drug.