Biosafety issues are the principles, policies, and procedures adopted to protect and safeguard the humans and environment.
It includes practices, strategies, and guides to prevent and check the environment's exposure to toxins and pathogens..
Biological hazards include viruses, bacteria, fungi, prions, and biologically derived toxins, which may be present in body fluids and tissue, cell culture specimens, and laboratory animals.
Routes of exposure for chemical and biological hazards include inhalation, ingestion, skin contact, and eye contact..
What are biological hazards or biohazards? Biohazards include biological agents and toxins infectious to humans, animals, wildlife, or plants such as parasites, viruses, bacteria, fungi, prions; and biologically-active materials such as toxins, allergens, and venoms..
A laboratory that provides the top level of security (BSL-4 laboratory) allows scientists to handle pathogens of the highest Risk Group 4, such as Ebola, Lassa and Nipah viruses..
Biohazard Level 4 usually includes dangerous viruses like Ebola, Marburg virus, Lassa fever, Bolivian hemorrhagic fever, and many other hemorrhagic viruses found in the tropics..
Whereas biosafety aims at protecting public health and environment from accidental exposure to biological agents, biosecurity deals with the prevention of misuse through loss, theft, diversion or intentional release of pathogens, toxins and any other biological materials..
Common examples of microbes found in BSL-3 labs include yellow fever, West Nile virus, and the bacteria that causes tuberculosis.
Microbes found within biosafety level 3 settings are so serious that work is often strictly controlled and registered through the appropriate government agencies..
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Examples of such measures include: biosafety cabinets; personal protective equipment including masks, gloves, safety glasses, and lab coats; hand washing; and..
Whereas biosafety aims at protecting public health and environment from accidental exposure to biological agents, biosecurity deals with the prevention of misuse through loss, theft, diversion or intentional release of pathogens, toxins and any other biological materials..
The appropriate BSL to be assigned to a project is determined by institutional biosafety committees (IBCs) or professionals, and reflects the specific combinations of specially designed buildings, safety equipment and safe work practices that laboratory workers must use..
The major issues associated with certification and validation of a biosafety laboratory remain misunderstood by laboratory managers/principal investigators (PIs) and other stakeholders and very often even by the external experts who are invited as committee members to validate biosafety laboratories.
Conflicts of Interest:
In the context of a biosafety laboratory, the reagents, tests and equipment, the validation is a process that determines the fitness of these, which has been properly developed, optimized and standardized, for an intended purpose.
Validation also includes ,estimates of the analytical and diagnostic performance characteristics of a test 10.
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