Baculovirus biosafety level

  • Is AAV bsl1 or bsl2?

    Historically, the IBC has assigned all work with AAV/rAAV to Biosafety Level 2 (BSL-2) or Animal Biosafety Level 2 (ABSL-2)..

  • What biosafety level is the Ebola virus?

    Ebola virus (EBOV) is a highly contagious lethal pathogen.
    As a biosafety level 4 (BSL-4) agent, however, EBOV is restricted to costly BSL-4 laboratories for experimentation, thus significantly impeding the evaluation of EBOV vaccines and drugs..

  • What viruses are in BSL 1?

    Biohazard Level 1 usually includes viruses and bacteria like Escherichia coli and chickenpox and many non-infectious bacteria.
    The level of precaution at this level is minimal and usually involves wearing a face mask and no close contact..

  • Baculoviruses are classified into the four genera Alphabaculovirus, Betabaculovirus, Gammabaculovirus and Deltabaculovirus.
    Figure 3.
    Baculoviridae.
    Phylogeny of family Baculoviridae.
  • Historically, the IBC has assigned all work with AAV/rAAV to Biosafety Level 2 (BSL-2) or Animal Biosafety Level 2 (ABSL-2).
The MUSC Institutional Biosafety Committee requires Biosafety Level 2 (BSL-2) containment and safety practices for work involving Baculovirus. Baculovirus is a lytic virus, primarily pathogenic for insects.
Thus while baculovirus is mainly infective for insect cells, some recombinant baculovirus vectors can infect mammalian cells and should therefore be handled under BL2 conditions.

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