How is Plasmodium falciparum classified?
P. falciparum is therefore regarded as the deadliest parasite in humans.
It is also associated with the development of blood cancer (Burkitt's lymphoma) and is classified as a Group 2A (probable) carcinogen.
The species originated from the malarial parasite Laverania found in gorillas, around 10,000 years ago..
What BSL level is Plasmodium falciparum?
Parasite
RG-2 | BSL-2 | .What classification is Plasmodium?
Plasmodium is a member of the phylum Apicomplexa, a large group of parasitic eukaryotes.
Within Apicomplexa, Plasmodium is in the order Haemosporida and family Plasmodiidae..
What is the pathogenicity of Plasmodium falciparum?
The pathogenesis of human P falciparum infection is a complex interplay of parasite-induced RBC alterations2 and microcirculatory abnormalities,12 accompanied by local and systemic immune reactions, resulting in multiple clinical forms of variable severity..
Why is Plasmodium falciparum the most pathogenic?
The virulence of P. falciparum is mediated by erythrocyte membrane proteins, which are produced by the schizonts and trophozoites inside the erythrocytes and are displayed on the erythrocyte membrane.
PfEMP1 is the most important, capable of acting as both an antigen and an adhesion molecule..
Why P. falciparum is the deadliest?
Unlike other Plasmodium species, P. falciparum infect all types of RBCs found at different stages of development (from immature young to old RBCs).
With additional hemolysis of noninfected RBCs by host immunity, the likely occurrence of severe anemia in P. falciparum infected children is high..
- ChromistaPlasmodium / Kingdom
- P. falciparum rings have delicate cytoplasm and one or two small chromatin dots.
Rbcs that are infected are not enlarged; multiple infection of rbcs is more common in P. falciparum than in other species. - Unlike other Plasmodium species, P. falciparum infect all types of RBCs found at different stages of development (from immature young to old RBCs).
With additional hemolysis of noninfected RBCs by host immunity, the likely occurrence of severe anemia in P. falciparum infected children is high.
