Leishmania tarentolae biosafety

  • Since isolation from its lizard host Tarentola mauretanica in 1921, L. tarentolae was kept in axenic culture.
    It is not pathogenic to mammalians and is fully approved for use in biosafety level 1 (S1) laboratories.
Leishmania tarentolae is a unicellular, flagellated protozoan organism and belongs to a family of parasites shuttling between sandflies and vertebrates.
Since isolation from its lizard host Tarentola mauretanica in 1921, L. tarentolae was kept in axenic culture. It is not pathogenic to mammalians and is fully approved for use in biosafety level 1 (S1) laboratories.

Can humans eat Sauroleishmania adleri & tarentolae?

The subgenus of

  • L. (Sauroleishmania) mostly contains species that are infectious to reptiles, but some species and strains, such as:
  • L. adleri and
  • L. tarentolae strain
  • LEM-125, were also shown to be (transiently) infectious to humans.
    However, most strains of
  • L. tarentolae are nonpathogenic to humans and can be easily handled as laboratory culture.

    • Does ppsp15 protect against Leishmania tarentolae?

    Katebi A, Gholami E, Taheri T, Zahedifard F, Habibzadeh S, Taslimi Y, et al.
    Leishmania tarentolae secreting the sand fly salivary antigen PpSP15 confers protection against Leishmania major infection in a susceptible BALB/c mice model.
    Molecular immunology. 2015;67 (2 Pt B):501–11. pmid:26298575. 174.

    Is Leishmania tarentolae biosafe?

    As this species belongs to the genus Leishmania and subgenus L. (Sauroleishmania), and because many Leishmania are human-pathogenic, the taxonomic status and phylogenetic position of L. tarentolae are relevant for biosafety and also discussed herein.

    What genus is Leishmania tarentolae?

    A phylogeny-based classification of the genus Leishmania.
    L. tarentolae belongs to the subgenus of Sauroleishmania, which is made up of mostly lizard-infecting parasites.
    Adapted from [ 1].
    The current controversy is centred around the taxonomic status of the subclades of the Paraleishmania section.


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