The Guangdong-Hong Kong-Macao Greater Bay Area (GBA) comprises the two Special Administrative Regions of Hong Kong and Macao, and the nine municipalities of Guangzhou, Shenzhen, Zhuhai, Foshan, Huizhou, Dongguan, Zhongshan, Jiangmen and Zhaoqing in Guangdong Province.
The total area is around 56 000 km2..
The GBA gene provides instructions for making an enzyme called beta-glucocerebrosidase.
This enzyme is active in lysosomes, which are structures inside cells that act as recycling centers.Mar 29, 2021.
Glucocerebroside is a normal component of cell membranes.
As senescent cells are degraded, macrophages engulf the cellular debris as a part of routine cell turnover.
The absence of β-glucosidase leads to accumulation of glucocerebroside in the lysosomes of macrophages..
GBA is located on chromosome 1q21 and there is a highly homologous pseudogene sequence located only 16 kb downstream.
There are approximately 300 described mutations in GBA, some of which originate from pseudogene sequences.
The N370S mutation accounts for about 70% of mutant alleles in the Ashkenazi Jewish population..
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