Zika virus biosafety level

  • How does Zika work at a cellular level?

    ZIKV exhibits preferential infection of neural progenitor cells, leading to cell-cycle arrest, increased apoptosis, and inhibition of NPC differentiation.
    All of these outcomes following ZIKV infection are associated with delayed development and birth defects, such as microcephaly in the mouse model [30]..

  • What biosafety level is Flavivirus?

    Flaviviruses associated with severe infections in humans such as Japanese encephalitis virus, Murray Valley encephalitis virus, Powassan virus, St.
    Louis Encephalitis virus, West Nile virus, and Yellow fever virus are classified as Risk Group-3 (RG-3) pathogens and require BSL-3 containment and work practices..

  • What category is the Zika virus in?

    Introduction. Zika virus is a member of the Flaviviridae family and the genus Flavivirus (which includes yellow fever virus, West Nile virus, Japanese encephalitis virus, and dengue virus).
    It is enveloped and icosahedral with a non-segmented, single-stranded, positive-sense RNA genome..

  • What is the lab test for Zika virus?

    Various Zika virus NAATs can be used on serum, plasma, whole blood, cerebrospinal fluid, urine, or amniotic fluid.
    FDA has cleared one enzyme immunoassay to detect Zika virus IgM antibodies in serum and currently has issued Emergency Use Authorizations for other IgM antibody assays to diagnose Zika virus infection..

  • What is unique about Zika virus?

    Zika can be passed from a pregnant woman to her fetus.
    Infection during pregnancy can cause certain birth defects.
    There is no vaccine or medicine for Zika..

  • Where is Zika virus a risk?

    Check if you're at risk of Zika virus
    South and Central America. the Caribbean. the Pacific islands.
    Africa..

  • Where was Zika virus identified?

    Zika virus is a mosquito-borne virus first identified in Uganda in 1947 in a Rhesus macaque monkey followed by evidence of infection and disease in humans in other African countries in the 1950s.
    From the 1960s to 1980s, sporadic human infections were detected across Africa and Asia..

  • Why is Zika virus a public health issue?

    The virus can cause microcephaly, which severely limits brain development among fetuses and newborns, and other serious birth defects. Zika is also linked to Guillain-Barré syndrome, a condition that damages the nervous system..

  • Zika-Free Beach Destinations: The Top 10 Safe Islands & Resort Locations

    Bermuda.
    Bermuda beach. Ibiza, Spain.
    Courtesy Gecko Beach Club. Great Barrier Reef.
    Courtesy Qualia. Seychelles.
    Courtesy North Island, Andrew Howard. Santorini.
    Courtesy Grace Santorini. Croatian Islands. French Polynesia. Hawaii.
  • In February 2016, the WHO declared the outbreak a Public Health Emergency of International Concern as evidence grew that Zika can cause birth defects as well as neurological problems.
  • Transmission. Zika virus is transmitted by mosquitoes.
    It has been isolated from Aedes aegypti mosquitoes and experimental infections show that this species is capable of transmitting Zika virus.
    Other Aedes mosquito species (notably Ae.
Generally, work with samples of Zika virus can be done at Biosafety Level 2. Limit access to active work areas and conduct aerosol-generating procedures in biosafety cabinets or other containment devices. Workers should always report exposure incidents, including sharps injuries, to their supervisor.
Generally, work with samples of Zika virus can be done at Biosafety Level 2.
Generally, work with samples of Zika virus can be done at Biosafety Level 2. Limit access to active work areas and conduct aerosol-generating procedures in biosafety cabinets or other containment devices. Workers should always report exposure incidents, including sharps injuries, to their supervisor.
Working with Zika Virus in the Laboratory Animal studies involving Zika virus may be performed under Animal Biosafety Level 2 precautions, as described in the CDC/NIH BMBL5.

Can Zika be studied in animals?

Animal studies involving Zika virus may be performed under Animal Biosafety Level 2 precautions, as described in the CDC/NIH BMBL5.
A risk assessment should be performed to determine if there are certain procedures that may require higher levels of biocontainment such as:

  • those that could potentially create aerosols.

    • What are the clinical criteria for Zika virus screening?

    The MOH recommended Zika virus screening for persons with fever and maculopapular rash, and 1 of the following:

  • arthralgia
  • myalgia
  • headache
  • and nonpurulent conjunctivitis.
    Clinical criteria for disease surveillance are a balancing act for satisfying 2 potentially conflicting needs:sensitivity and specificity.

    • What is the biological safety level assigned to Zika virus?

    Answer (1 of 2):

  • The biological safety level assigned to Zika virus is BSL-2.
    BSL-2 laboratories have the following containment requirements:Laboratory practices * Access to the laboratory is restricted when work is being conducted.
    Safety equipment * Appropriate personal protective equip..

    • What is Zika testing?

    Testing detects the genetic material ( RNA) of the Zika virus in blood, urine, cerebrospinal fluid (CSF), or amniotic fluid or detects antibodies in the blood produced in response to Zika virus infection.
    About 80% of individuals infected with Zika virus will have no symptoms at all, while others will have only mild illness.


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