Computational biology hypothesis

  • Computational biology Subjects

    The abstraction principle that represents biological entities as interacting computational units is the basis of the computational thinking that can help biology to unravel the functions of the cell machinery..

  • How is computational thinking used in biology?

    The abstraction principle that represents biological entities as interacting computational units is the basis of the computational thinking that can help biology to unravel the functions of the cell machinery..

  • What is an example of a hypothesis in biology?

    For example, a scientist can form a hypothesis stating that if a certain type of tomato has a gene for red pigment, that type of tomato will be red.
    During research, the scientist then finds that each tomato of this type is red..

  • What is the computational approach in biology?

    Computational biology is the science that answers the question “How can we learn and use models of biological systems constructed from experimental measurements?” These models may describe what biological tasks are carried out by particular nucleic acid or peptide sequences, which gene (or genes) when expressed produce .

  • What is the goal of computational biology?

    A fundamental goal of computational biology is the prediction of protein structure from an amino acid sequence.
    The spontaneous folding of proteins shows that this should be possible..

  • Biological (Scientific) hypothesis: An idea that proposes a tentative explanation about a phenomenon or a narrow set of phenomena observed in the natural world.
    This is the backbone of all scientific inquiry
Nov 23, 2017Now, with the emergence of large data sets across biomedicine, computational biologists can contribute not only to testing hypotheses, but also 
Nov 23, 2017The ability to generate and test a hypothesis has always been the cornerstone of science. Bioinformaticians have classically used complex 
Sep 3, 2020But when we analyze the results of an experiment, our mental focus on a specific hypothesis can prevent us from exploring other aspects of the 
Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships 
Computational biology hypothesis
Computational biology hypothesis
The ambush hypothesis is a hypothesis in the field of molecular genetics that suggests that the prevalence of “hidden” or off-frame stop codons in DNA selectively deters off-frame translation of mRNA to save energy, molecular resources, and to reduce strain on biosynthetic machinery by truncating the production of non-functional, potentially cytotoxic protein products.
Typical coding sequences of DNA lack in-frame internal stop codons to avoid the premature reduction of protein products when translation proceeds normally.
The ambush hypothesis suggests that kinetic, cis-acting mechanisms are responsible for the productive frameshifting of translational units so that the degeneracy of the genetic code can be used to prevent deleterious translation.
Ribosomal slippage is the most well described mechanism of translational frameshifting where the ribosome moves one codon position either forward (+1) or backward (-1) to translate the mRNA sequence in a different reading frame and thus produce different protein products.

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