Crystallography of dna

  • How was the structure of DNA discovered?

    The discovery of the structure of DNA in 1953 was made possible by Dr Rosalind Franklin's X-ray diffraction work at King's.
    Her creation of the famous Photo 51 demonstrated the double-helix structure of deoxyribonucleic acid: the molecule containing the genetic instructions for the development of all living organisms..

  • Who actually took photo 51?

    The photo was taken in May 1952 by Rosalind Franklin and her PhD student Raymond Gosling in the basement underneath the chemistry laboratories at the MRC Biophysics Unit.
    Franklin, a biophysicist, had been recruited to the unit to work on the structure of DNA..

  • A more enduring controversy has been generated by Watson and Crick's use of Rosalind Franklin's crystallographic evidence of the structure of DNA, which was shown to them, without her knowledge, by her estranged colleague, Maurice Wilkins, and by Max Perutz.
  • The diffraction pattern determined the helical nature of the double helix strands (antiparallel).
    The outside of the DNA chain has a backbone of alternating deoxyribose and phosphate moieties, and the base pairs, the order of which provides codes for protein building and thereby inheritance, are inside the helix.
Crystallography of dna
Crystallography of dna
Rosalind Franklin and DNA is a biography of an English chemist Rosalind Franklin (1920–1958) written by her American friend Anne Sayre in 1975.
Franklin was a physical chemist who made pivotal research in the discovery of the structure of DNA, known as the most important discovery in biology.
DNA itself had become life's most famous molecule.
While working at the King's College London in 1951, she discovered two types of DNA called A-DNA and B-DNA.
Her X-ray images of DNA indicated helical structure.
Her X-ray image of B-DNA taken in 1952 became the best evidence for the structure of DNA.
For the discovery of the correct chemical structure of DNA, the Nobel Prize in Physiology or Medicine 1962 was shared by her colleagues and close researchers James Watson, Francis Crick and Maurice Wilkins; she had died four years earlier in 1958 making her ineligible for the award.

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