Cytology vs cell block

  • What is cytology and cell block?

    Cell blocks are preparations in which cytologic material is collected and processed as a paraffin embedded block in a manner that is comparable to formalin-fixed paraffin-embedded tissue in surgical pathology..

  • A cell block can be obtained by expressing the contents of the aspirated specimen onto a glass slide.
    This allows the specimen to dry/clot; the material can then be scraped off the slide and wrapped in tissue paper.
CB is used to establish a more definitive diagnosis adjuncts to cytological smear especially in categorization of tumor (1). Cytological smear is superior to the CB, the cell examined by cytological smear is much larger than that examined by CB, quick in process and less expensive (2).
CB is used to establish a more definitive diagnosis adjuncts to cytological smear especially in categorization of tumor (1). Cytological smear is superior to the CB, the cell examined by cytological smear is much larger than that examined by CB, quick in process and less expensive (2).

Are cytospin preparations better than cell blocks?

We observed that overall, cell yield and preservation of individual cell morphology were better in cytospin preparations as compared to cell blocks, while preservation of architectural pattern was better in cell block sections.
The number of suspicious cases also decreased on cell block sections, with increased detection of malignancy.

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Can cytological smear and cell block be used to diagnose non-gynaecologic specimens?

Background Cytological smear and cell block (CB) are routinely used to diagnose non-gynaecologic specimens.
However, there is scanty information in the literature to compare cytological smear and CB with the corresponding tissue biopsies.

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What is a Cell Block in cytology?

Cell Block in Cytological Diagnostics:

  1. Review of Preparatory Techniques In the CBs
  2. the cytological material is preserved for future use
  3. which is a tremendous advantage in the era of targeted therapy and biobanking

The CB is thus central to the future of cytology:more can be done with less material and with less invasiveness to the patient.
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What is Cell Block preparation?

Cell block preparation, as opposed to tissue processing in surgical pathology, is more variable with many different protocols in use today.
This review explores the most commonly used cell block preparation techniques currently in use with review of the unique advantages and limitations each method presents.

Medical condition

Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer, currently classified as a variant of large cell lung carcinoma (LCLC).
In order for a LCLC to be subclassified as the extiw>rhabdoid phenotype variant, at least 10% of the malignant tumor cells must contain distinctive structures composed of tangled intermediate filaments that displace the cell nucleus outward toward the cell membrane.
The whorled eosinophilic inclusions in LCLC-RP cells give it a microscopic resemblance to malignant cells found in rhabdomyosarcoma (RMS), a rare neoplasm arising from transformed skeletal muscle.
Despite their microscopic similarities, LCLC-RP is not associated with rhabdomyosarcoma.

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