This group of tumor includes entities such as peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, neuroblastoma, hepatoblastoma, Wilms' tumor, and desmoplastic small round cell tumor..
Background.
Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive neoplasm.
The cytological diagnosis of these tumors can be difficult because they show morphological features quite similar to other small round blue cells tumors..
Malignant small round cell tumors are characterised by small, round, relatively undifferentiated cells.
They generally include Ewing's sarcoma, peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, retinoblastoma, neuroblastoma, hepatoblastoma, and nephroblastoma or Wilms' tumor..
Malignant small round cell tumors are characterised by small, round, relatively undifferentiated cells.
They generally include Ewing's sarcoma, peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, retinoblastoma, neuroblastoma, hepatoblastoma, and nephroblastoma or Wilms' tumor..
The cytological smears of DSRCT obtained by FNAB are moderately cellular.
Tumor cells show round to oval nuclei with fine chromatin and inconspicuous nucleoli.
Cytoplasm is scanty to moderate, with variable number of vacuoles.
Tumor cells are arranged in loose clusters..
Malignant small round cell tumors are characterised by small, round, relatively undifferentiated cells.
They generally include Ewing's sarcoma, peripheral neuroectodermal tumor, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, retinoblastoma, neuroblastoma, hepatoblastoma, and nephroblastoma or Wilms' tumor..
Group of tumours that is typically seen in childhood and younger adults.
Gino's panel: More general panel:.
1) CD45, CD20, CD3, CD99, desmin, EMA, pankeratin, synaptophysin, chromogranin, GFAP.
Features:.
1) Small cells ~ 2X RBC diameter - key feature.
2) Scant cytoplasm/high NC ratio.
3) Sheets of cells, very cellular.
4) Coarse chromatin. 5. +/-Nucleolus; usu. not prominent. 6. +/-Vascularity.
Other differential diagnoses of small round cell tumors include:
Malignant small round cell tumors are characterised by small, round, relatively undifferentiated cells.
They generally include:
Micrograph showing a small round cell tumour ( Ewing sarcoma) in the lung.
H&E stain.
Small round cell tumours (SRCT), also small round blue cell tumours (SRBCT), are a group of tumours that have a similar histologic appearance.
Group of tumours that is typically seen in childhood and younger adults.
