The histopathology of BCC is largely characterized by aggregates of basal cells with a small cytoplasm and large, hyperchromatic nuclei, apoptotic cells, all included in a fibromyxoid stroma, with tumor retraction spaces..
A small pink growth with a slightly raised, rolled edge and a crusted indentation in the center that may develop tiny surface blood vessels over time.
A scar-like area that is flat white, yellow or waxy in color.
The skin appears shiny and taut, often with poorly defined borders..
Your doctor may do a skin biopsy, which involves removing a small sample of a lesion for testing in a laboratory.
This will reveal whether you have skin cancer and, if so, what type of skin cancer.
The type of skin biopsy you undergo will depend on the type and size of the lesion..
The histopathology of BCC is largely characterized by aggregates of basal cells with a small cytoplasm and large, hyperchromatic nuclei, apoptotic cells, all included in a fibromyxoid stroma, with tumor retraction spaces..
Cytologic features suggestive of basal cell carcinoma included increased numbers of small, uniform hyperchromatic, relatively little cytoplasmic cell clusters.
The peripheral cells appeared in monolayer form as a papillated outline with very strong cellular cohesion.
Scattered tumor cells were seldom seen..
Histology of basal cell carcinoma
The key feature of basal cell carcinoma at low power magnification is of a basaloid epithelial tumour arising from the epidermis (figure 1).
The basaloid epithelium typically forms a palisade with a cleft forming from the adjacent tumour stroma (figure 2)..
To determine the diagnostic accuracy of exfoliative cytology for detecting basal cell carcinoma (BCC) in adults, and to compare its accuracy with that of standard diagnostic practice (visual inspection with or without dermoscopy).
The key feature of basal cell carcinoma at low power magnification is of a basaloid epithelial tumour arising from the epidermis (figure 1).
The basaloid epithelium typically forms a palisade with a cleft forming from the adjacent tumour stroma (figure 2).
Centrally the nuclei become crowded with scattered mitotic figures and necrotic bodies eviden.
Basal cell carcinoma stains positively with cytokeratin, though favouring cytokeratins from the follicularepithelium.
BerEP4 is diffusely present in most tumours, while EMA is infrequently positive.
Superficial BCC: This variant show multifocal nests of atypical basaloid epithelium arising as buds from the basal layer of the epidermis.
These nests remain confined to the papillary dermis(Figure 5) Nodular BCC: The tumour forms a solid tumour nodule or nodules which may extend into subcutaneoustissues.
Cartilaginous invasion is unusual (figure 1.
Summary ROC plot of exfoliative cytology to detect BCC in patients with suspected BCCs, showing classification of 'possible BCCs' as test positives or as test negatives.
BCC:
Basal cell carcinoma (BCC) arises from the interfollicular or follicular epithelium Low disease associated death rate; metastases to lung and bone exceptionally rare When multiple, associated with a number of genetic conditions, including:
Basosquamous or metatypical BCC shows features of both BCC and SCC.
The exact nature of this lesion is controversial, but most reserve this term for the rare basal cell carcinoma composed of nests and strands of cells maturing into larger and paler cells without peripheral palisading.
